Publication

Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

Psychiat Genomics Consortium, 15-Oct-2019, In : Biological Psychiatry. 86, 8, p. 577-586 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Psychiat Genomics Consortium (2019). Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry, 86(8), 577-586. https://doi.org/10.1016/j.biopsych.2019.04.036

Author

Psychiat Genomics Consortium. / Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders : A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. In: Biological Psychiatry. 2019 ; Vol. 86, No. 8. pp. 577-586.

Harvard

Psychiat Genomics Consortium 2019, 'Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches', Biological Psychiatry, vol. 86, no. 8, pp. 577-586. https://doi.org/10.1016/j.biopsych.2019.04.036

Standard

Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders : A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. / Psychiat Genomics Consortium.

In: Biological Psychiatry, Vol. 86, No. 8, 15.10.2019, p. 577-586.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Psychiat Genomics Consortium. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry. 2019 Oct 15;86(8):577-586. https://doi.org/10.1016/j.biopsych.2019.04.036


BibTeX

@article{85e9fb785f0a43c88a1b41ab1f59050f,
title = "Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches",
abstract = "BACKGROUND: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently cooccur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa.METHODS: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472).RESULTS: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95{\%} confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95{\%} CI = 2.15, 2.86; other EDs: OR = 4.66, 95{\%} CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95{\%} CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95{\%} CI = .31, .42) than with AN (.14, 95{\%} CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes.CONCLUSIONS: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.",
keywords = "ADHD, Anorexia nervosa, Bulimia nervosa, Eating disorders, Genetic epidemiology, Polygenic risk score, ANOREXIA-NERVOSA, ADULTS, LISDEXAMFETAMINE, CHILDHOOD, OVERWEIGHT/OBESITY, COMORBIDITY, MORTALITY, LIABILITY, SYMPTOMS",
author = "{Psychiat Genomics Consortium} and Shuyang Yao and Ralf Kuja-Halkola and Joanna Martin and Yi Lu and Paul Lichtenstein and Claes Norring and Andreas Birgegard and Zeynep Yilmaz and Christopher Hubel and Hunna Watson and Jessica Baker and Catarina Almqvist and Thornton, {Laura M.} and Magnusson, {Patrik K.} and Bulik, {Cynthia M.} and Henrik Larsson and Roger Adan and Tetsuya Ando and Andrew Bergen and Wade Berrettini and Claudette Boni and Perica, {Vesna Boraska} and Harry Brandt and Roland Burghardt and Matteo Cassina and Carolyn Cesta and Maurizio Clementi and Joni Coleman and Roger Cone and Philippe Courtet and Steven Crawford and Scott Crow and James Crowley and Unna Danner and Oliver Davis and {de Zwaan}, Martina and George Dedoussis and Daniela Degortes and Janiece DeSocio and Danielle Dick and Dimitris Dikeos and Monika Dmitrzak-Weglarz and Elisa Docampo and Karin Egberts and Stefan Ehrlich and Georgia Escaramis and Tonu Esko and Xavier Estivill and Martien Kas and Dong Li",
year = "2019",
month = "10",
day = "15",
doi = "10.1016/j.biopsych.2019.04.036",
language = "English",
volume = "86",
pages = "577--586",
journal = "Biological Psychiatry",
issn = "1873-2402",
publisher = "ELSEVIER SCIENCE INC",
number = "8",

}

RIS

TY - JOUR

T1 - Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders

T2 - A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

AU - Psychiat Genomics Consortium

AU - Yao, Shuyang

AU - Kuja-Halkola, Ralf

AU - Martin, Joanna

AU - Lu, Yi

AU - Lichtenstein, Paul

AU - Norring, Claes

AU - Birgegard, Andreas

AU - Yilmaz, Zeynep

AU - Hubel, Christopher

AU - Watson, Hunna

AU - Baker, Jessica

AU - Almqvist, Catarina

AU - Thornton, Laura M.

AU - Magnusson, Patrik K.

AU - Bulik, Cynthia M.

AU - Larsson, Henrik

AU - Adan, Roger

AU - Ando, Tetsuya

AU - Bergen, Andrew

AU - Berrettini, Wade

AU - Boni, Claudette

AU - Perica, Vesna Boraska

AU - Brandt, Harry

AU - Burghardt, Roland

AU - Cassina, Matteo

AU - Cesta, Carolyn

AU - Clementi, Maurizio

AU - Coleman, Joni

AU - Cone, Roger

AU - Courtet, Philippe

AU - Crawford, Steven

AU - Crow, Scott

AU - Crowley, James

AU - Danner, Unna

AU - Davis, Oliver

AU - de Zwaan, Martina

AU - Dedoussis, George

AU - Degortes, Daniela

AU - DeSocio, Janiece

AU - Dick, Danielle

AU - Dikeos, Dimitris

AU - Dmitrzak-Weglarz, Monika

AU - Docampo, Elisa

AU - Egberts, Karin

AU - Ehrlich, Stefan

AU - Escaramis, Georgia

AU - Esko, Tonu

AU - Estivill, Xavier

AU - Kas, Martien

AU - Li, Dong

PY - 2019/10/15

Y1 - 2019/10/15

N2 - BACKGROUND: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently cooccur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa.METHODS: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472).RESULTS: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes.CONCLUSIONS: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.

AB - BACKGROUND: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently cooccur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa.METHODS: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472).RESULTS: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes.CONCLUSIONS: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.

KW - ADHD

KW - Anorexia nervosa

KW - Bulimia nervosa

KW - Eating disorders

KW - Genetic epidemiology

KW - Polygenic risk score

KW - ANOREXIA-NERVOSA

KW - ADULTS

KW - LISDEXAMFETAMINE

KW - CHILDHOOD

KW - OVERWEIGHT/OBESITY

KW - COMORBIDITY

KW - MORTALITY

KW - LIABILITY

KW - SYMPTOMS

U2 - 10.1016/j.biopsych.2019.04.036

DO - 10.1016/j.biopsych.2019.04.036

M3 - Article

VL - 86

SP - 577

EP - 586

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 1873-2402

IS - 8

ER -

ID: 99792164