Publication

Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma

Diepstra, A., Niens, M., Vellenga, E., van Imhoff, GW., Nolte, IM., Schaapveld, M., van der Steege, G., van den Berg, A., Kibbelaar, RE., te Meerman, GJ. & Poppema, S., 25-Jun-2005, In : LANCET. 365, 9478, p. 2216-2224 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Diepstra, A., Niens, M., Vellenga, E., van Imhoff, GW., Nolte, IM., Schaapveld, M., ... Poppema, S. (2005). Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma. LANCET, 365(9478), 2216-2224.

Author

Diepstra, A ; Niens, M ; Vellenga, E ; van Imhoff, GW ; Nolte, IM ; Schaapveld, M ; van der Steege, G ; van den Berg, Anke ; Kibbelaar, RE ; te Meerman, GJ ; Poppema, S. / Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma. In: LANCET. 2005 ; Vol. 365, No. 9478. pp. 2216-2224.

Harvard

Diepstra, A, Niens, M, Vellenga, E, van Imhoff, GW, Nolte, IM, Schaapveld, M, van der Steege, G, van den Berg, A, Kibbelaar, RE, te Meerman, GJ & Poppema, S 2005, 'Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma' LANCET, vol. 365, no. 9478, pp. 2216-2224.

Standard

Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma. / Diepstra, A; Niens, M; Vellenga, E; van Imhoff, GW; Nolte, IM; Schaapveld, M; van der Steege, G; van den Berg, Anke; Kibbelaar, RE; te Meerman, GJ; Poppema, S.

In: LANCET, Vol. 365, No. 9478, 25.06.2005, p. 2216-2224.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Diepstra A, Niens M, Vellenga E, van Imhoff GW, Nolte IM, Schaapveld M et al. Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma. LANCET. 2005 Jun 25;365(9478):2216-2224.


BibTeX

@article{42a19caa04b04742a40fb49fcc9c855c,
title = "Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma",
abstract = "Background Associations of Hodgkin's lymphoma with HLA have been reported for many years. In 20-40{\%} of patients with this disorder, Epstein-Barr virus (EBV) is present in the neoplastic cells. Because presentation of EBV antigenic peptides can elicit vigorous immune responses, we investigated associations of the HLA region with EBV-positive and EBV-negative Hodgkin's lymphoma.Methods In a retrospective, population-based study, patients with Hodgkin's lymphoma were reclassified according to the WHO classification, and EBV status was assessed by in-situ hybridisation of EBV-encoded small RNAs. Germline DNA was isolated from 200 patients diagnosed between 1987 and 2000 and from their first-degree relatives. Genotyping was done with 33 microsatellite markers spanning the entire HLA region and two single-nucleotide polymorphisms in the genes for tumour necrosis factor alpha and beta. Classic association analysis and the haplotype sharing statistic were used to compare patients with controls.Findings Classic association analysis (but not the haplotype sharing statistic) showed an association of consecutive markers D6S265 and D6S510 (p=0.0002 and 0.0003), located in the HLA class I region, with EBV-positive lymphomas. The haplotype sharing statistic (but not classic association analysis) showed a significant difference in mean haplotype sharing between patients and controls surrounding marker D6S273 (p=0.00003), located in HLA class III.Interpretation Areas within the HLA class I and class III regions are associated with susceptibility to Hodgkin's lymphoma, the association with class I being specific for EBV-positive disease. This finding strongly suggests that antigenic presentation of EBV-derived peptides is involved in the pathogenesis of EBV-involved Hodgkin's lymphoma.Relevance to practice Polymorphisms in the HLA region could explain ethnic variation in the incidence of Hodgkin's lymphoma. The association of EBV-positive Hodgkin's lymphoma with HLA class I suggests that this polymorphism might affect the proper presentation of EBV antigens to cytotoxic T lymphocytes.",
keywords = "REED-STERNBERG CELLS, MAJOR HISTOCOMPATIBILITY COMPLEX, DISEASE, GENE, SUSCEPTIBILITY, POLYMORPHISM, POPULATION, EXPRESSION, PATTERNS, SUGGESTS",
author = "A Diepstra and M Niens and E Vellenga and {van Imhoff}, GW and IM Nolte and M Schaapveld and {van der Steege}, G and {van den Berg}, Anke and RE Kibbelaar and {te Meerman}, GJ and S Poppema",
note = "J rticle",
year = "2005",
month = "6",
day = "25",
language = "English",
volume = "365",
pages = "2216--2224",
journal = "The Lancet",
issn = "0140-6736",
publisher = "ELSEVIER SCIENCE INC",
number = "9478",

}

RIS

TY - JOUR

T1 - Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma

AU - Diepstra, A

AU - Niens, M

AU - Vellenga, E

AU - van Imhoff, GW

AU - Nolte, IM

AU - Schaapveld, M

AU - van der Steege, G

AU - van den Berg, Anke

AU - Kibbelaar, RE

AU - te Meerman, GJ

AU - Poppema, S

N1 - J rticle

PY - 2005/6/25

Y1 - 2005/6/25

N2 - Background Associations of Hodgkin's lymphoma with HLA have been reported for many years. In 20-40% of patients with this disorder, Epstein-Barr virus (EBV) is present in the neoplastic cells. Because presentation of EBV antigenic peptides can elicit vigorous immune responses, we investigated associations of the HLA region with EBV-positive and EBV-negative Hodgkin's lymphoma.Methods In a retrospective, population-based study, patients with Hodgkin's lymphoma were reclassified according to the WHO classification, and EBV status was assessed by in-situ hybridisation of EBV-encoded small RNAs. Germline DNA was isolated from 200 patients diagnosed between 1987 and 2000 and from their first-degree relatives. Genotyping was done with 33 microsatellite markers spanning the entire HLA region and two single-nucleotide polymorphisms in the genes for tumour necrosis factor alpha and beta. Classic association analysis and the haplotype sharing statistic were used to compare patients with controls.Findings Classic association analysis (but not the haplotype sharing statistic) showed an association of consecutive markers D6S265 and D6S510 (p=0.0002 and 0.0003), located in the HLA class I region, with EBV-positive lymphomas. The haplotype sharing statistic (but not classic association analysis) showed a significant difference in mean haplotype sharing between patients and controls surrounding marker D6S273 (p=0.00003), located in HLA class III.Interpretation Areas within the HLA class I and class III regions are associated with susceptibility to Hodgkin's lymphoma, the association with class I being specific for EBV-positive disease. This finding strongly suggests that antigenic presentation of EBV-derived peptides is involved in the pathogenesis of EBV-involved Hodgkin's lymphoma.Relevance to practice Polymorphisms in the HLA region could explain ethnic variation in the incidence of Hodgkin's lymphoma. The association of EBV-positive Hodgkin's lymphoma with HLA class I suggests that this polymorphism might affect the proper presentation of EBV antigens to cytotoxic T lymphocytes.

AB - Background Associations of Hodgkin's lymphoma with HLA have been reported for many years. In 20-40% of patients with this disorder, Epstein-Barr virus (EBV) is present in the neoplastic cells. Because presentation of EBV antigenic peptides can elicit vigorous immune responses, we investigated associations of the HLA region with EBV-positive and EBV-negative Hodgkin's lymphoma.Methods In a retrospective, population-based study, patients with Hodgkin's lymphoma were reclassified according to the WHO classification, and EBV status was assessed by in-situ hybridisation of EBV-encoded small RNAs. Germline DNA was isolated from 200 patients diagnosed between 1987 and 2000 and from their first-degree relatives. Genotyping was done with 33 microsatellite markers spanning the entire HLA region and two single-nucleotide polymorphisms in the genes for tumour necrosis factor alpha and beta. Classic association analysis and the haplotype sharing statistic were used to compare patients with controls.Findings Classic association analysis (but not the haplotype sharing statistic) showed an association of consecutive markers D6S265 and D6S510 (p=0.0002 and 0.0003), located in the HLA class I region, with EBV-positive lymphomas. The haplotype sharing statistic (but not classic association analysis) showed a significant difference in mean haplotype sharing between patients and controls surrounding marker D6S273 (p=0.00003), located in HLA class III.Interpretation Areas within the HLA class I and class III regions are associated with susceptibility to Hodgkin's lymphoma, the association with class I being specific for EBV-positive disease. This finding strongly suggests that antigenic presentation of EBV-derived peptides is involved in the pathogenesis of EBV-involved Hodgkin's lymphoma.Relevance to practice Polymorphisms in the HLA region could explain ethnic variation in the incidence of Hodgkin's lymphoma. The association of EBV-positive Hodgkin's lymphoma with HLA class I suggests that this polymorphism might affect the proper presentation of EBV antigens to cytotoxic T lymphocytes.

KW - REED-STERNBERG CELLS

KW - MAJOR HISTOCOMPATIBILITY COMPLEX

KW - DISEASE

KW - GENE

KW - SUSCEPTIBILITY

KW - POLYMORPHISM

KW - POPULATION

KW - EXPRESSION

KW - PATTERNS

KW - SUGGESTS

M3 - Article

VL - 365

SP - 2216

EP - 2224

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9478

ER -

ID: 1675610