Publication

Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study

ASIAN-HF Investigators, Sep-2019, In : PLOS MEDICINE. 16, 9, 17 p., 1002916.

Research output: Contribution to journalArticleAcademicpeer-review

APA

ASIAN-HF Investigators (2019). Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. PLOS MEDICINE, 16(9), [1002916]. https://doi.org/10.1371/journal.pmed.1002916

Author

ASIAN-HF Investigators. / Association of obesity with heart failure outcomes in 11 Asian regions : A cohort study. In: PLOS MEDICINE. 2019 ; Vol. 16, No. 9.

Harvard

ASIAN-HF Investigators 2019, 'Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study', PLOS MEDICINE, vol. 16, no. 9, 1002916. https://doi.org/10.1371/journal.pmed.1002916

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Association of obesity with heart failure outcomes in 11 Asian regions : A cohort study. / ASIAN-HF Investigators.

In: PLOS MEDICINE, Vol. 16, No. 9, 1002916, 09.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

ASIAN-HF Investigators. Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. PLOS MEDICINE. 2019 Sep;16(9). 1002916. https://doi.org/10.1371/journal.pmed.1002916


BibTeX

@article{d6ba6631a4c741db888f2d1d0959a287,
title = "Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study",
abstract = "Background Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, are scarce in Asia and have only utilised the traditional classification of body mass index (BMI). We aimed to investigate the association between obesity (defined by BMI and abdominal measures) and HF outcomes in Asia. Methods and findings Utilising the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry (11 Asian regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia, Philippines, Japan, and Korea; 46 centres with enrolment between 1 October 2012 and 6 October 2016), we prospectively examined 5,964 patients with symptomatic HF (mean age 61.3 +/- 13.3 years, 26{\%} women, mean BMI 25.3 +/- 5.3 kg/m(2), 16{\%} with HF with preserved ejection fraction [HFpEF; ejection fraction >= 50{\%}]), among whom 2,051 also had waist-to-height ratio (WHtR) measurements (mean age 60.8 +/- 12.9 years, 24{\%} women, mean BMI 25.0 +/- 5.2 kg/m(2), 7{\%} HFpEF). Patients were categorised by BMI quartiles or WHtR quartiles or 4 combined groups of BMI (low, = 24.5 kg/m(2) [obese]) and WHtR (low, = 0.55 [fat]). Cox proportional hazards models were used to examine a 1-year composite outcome (HF hospitalisation or mortality). Across BMI quartiles, higher BMI was associated with lower risk of the composite outcome (p(trend) <0.001). Contrastingly, higher WHtR was associated with higher risk of the composite outcome. Individuals in the lean-fat group, with low BMI and high WHtR (13.9{\%}), were more likely to be women (35.4{\%}) and to be from low-income countries (47.7{\%}) (predominantly in South/Southeast Asia), and had higher prevalence of diabetes (46{\%}), worse quality of life scores (63.3 +/- 24.2), and a higher rate of the composite outcome (51/232; 22{\%}), compared to the other groups (p <0.05 for all). Following multivariable adjustment, the lean-fat group had higher adjusted risk of the composite outcome (hazard ratio 1.93, 95{\%} CI 1.17-3.18, p = 0.01), compared to the obese-thin group, with high BMI and low WHtR. Results were consistent across both HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]; p(interaction) = 0.355). Selection bias and residual confounding are potential limitations of such multinational observational registries. Conclusions In this cohort of Asian patients with HF, the 'obesity paradox' is observed only when defined using BMI, with WHtR showing the opposite association with the composite outcome. Lean-fat patients, with high WHtR and low BMI, have the worst outcomes. A direct correlation between high WHtR and the composite outcome is apparent in both HFpEF and HFrEF.",
keywords = "BODY-MASS INDEX, SUDDEN CARDIAC DEATH, MORTALITY, PARADOX, METAANALYSIS, ADIPOSITY, RISK, FAT",
author = "{ASIAN-HF Investigators} and Chanchal Chandramouli and Tay, {Wan Ting} and Bamadhaj, {Nurul Sahiddah} and Jasper Tromp and Teng, {Tiew-Hwa Katherine} and Yap, {Jonathan J. L.} and MacDonald, {Michael R.} and Chung-Lieh Hung and Koen Streng and Ajay Naik and Wander, {Gurpreet Singh} and Jitendra Sawhney and Ling, {Lieng Hsi} and Richards, {A. Mark} and Inder Anand and Voors, {Adriaan A.} and Lam, {Carolyn S. P.}",
year = "2019",
month = "9",
doi = "10.1371/journal.pmed.1002916",
language = "English",
volume = "16",
journal = "PLOS MEDICINE",
issn = "1549-1277",
publisher = "PUBLIC LIBRARY SCIENCE",
number = "9",

}

RIS

TY - JOUR

T1 - Association of obesity with heart failure outcomes in 11 Asian regions

T2 - A cohort study

AU - ASIAN-HF Investigators

AU - Chandramouli, Chanchal

AU - Tay, Wan Ting

AU - Bamadhaj, Nurul Sahiddah

AU - Tromp, Jasper

AU - Teng, Tiew-Hwa Katherine

AU - Yap, Jonathan J. L.

AU - MacDonald, Michael R.

AU - Hung, Chung-Lieh

AU - Streng, Koen

AU - Naik, Ajay

AU - Wander, Gurpreet Singh

AU - Sawhney, Jitendra

AU - Ling, Lieng Hsi

AU - Richards, A. Mark

AU - Anand, Inder

AU - Voors, Adriaan A.

AU - Lam, Carolyn S. P.

PY - 2019/9

Y1 - 2019/9

N2 - Background Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, are scarce in Asia and have only utilised the traditional classification of body mass index (BMI). We aimed to investigate the association between obesity (defined by BMI and abdominal measures) and HF outcomes in Asia. Methods and findings Utilising the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry (11 Asian regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia, Philippines, Japan, and Korea; 46 centres with enrolment between 1 October 2012 and 6 October 2016), we prospectively examined 5,964 patients with symptomatic HF (mean age 61.3 +/- 13.3 years, 26% women, mean BMI 25.3 +/- 5.3 kg/m(2), 16% with HF with preserved ejection fraction [HFpEF; ejection fraction >= 50%]), among whom 2,051 also had waist-to-height ratio (WHtR) measurements (mean age 60.8 +/- 12.9 years, 24% women, mean BMI 25.0 +/- 5.2 kg/m(2), 7% HFpEF). Patients were categorised by BMI quartiles or WHtR quartiles or 4 combined groups of BMI (low, = 24.5 kg/m(2) [obese]) and WHtR (low, = 0.55 [fat]). Cox proportional hazards models were used to examine a 1-year composite outcome (HF hospitalisation or mortality). Across BMI quartiles, higher BMI was associated with lower risk of the composite outcome (p(trend) <0.001). Contrastingly, higher WHtR was associated with higher risk of the composite outcome. Individuals in the lean-fat group, with low BMI and high WHtR (13.9%), were more likely to be women (35.4%) and to be from low-income countries (47.7%) (predominantly in South/Southeast Asia), and had higher prevalence of diabetes (46%), worse quality of life scores (63.3 +/- 24.2), and a higher rate of the composite outcome (51/232; 22%), compared to the other groups (p <0.05 for all). Following multivariable adjustment, the lean-fat group had higher adjusted risk of the composite outcome (hazard ratio 1.93, 95% CI 1.17-3.18, p = 0.01), compared to the obese-thin group, with high BMI and low WHtR. Results were consistent across both HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]; p(interaction) = 0.355). Selection bias and residual confounding are potential limitations of such multinational observational registries. Conclusions In this cohort of Asian patients with HF, the 'obesity paradox' is observed only when defined using BMI, with WHtR showing the opposite association with the composite outcome. Lean-fat patients, with high WHtR and low BMI, have the worst outcomes. A direct correlation between high WHtR and the composite outcome is apparent in both HFpEF and HFrEF.

AB - Background Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, are scarce in Asia and have only utilised the traditional classification of body mass index (BMI). We aimed to investigate the association between obesity (defined by BMI and abdominal measures) and HF outcomes in Asia. Methods and findings Utilising the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry (11 Asian regions including Taiwan, Hong Kong, China, India, Malaysia, Thailand, Singapore, Indonesia, Philippines, Japan, and Korea; 46 centres with enrolment between 1 October 2012 and 6 October 2016), we prospectively examined 5,964 patients with symptomatic HF (mean age 61.3 +/- 13.3 years, 26% women, mean BMI 25.3 +/- 5.3 kg/m(2), 16% with HF with preserved ejection fraction [HFpEF; ejection fraction >= 50%]), among whom 2,051 also had waist-to-height ratio (WHtR) measurements (mean age 60.8 +/- 12.9 years, 24% women, mean BMI 25.0 +/- 5.2 kg/m(2), 7% HFpEF). Patients were categorised by BMI quartiles or WHtR quartiles or 4 combined groups of BMI (low, = 24.5 kg/m(2) [obese]) and WHtR (low, = 0.55 [fat]). Cox proportional hazards models were used to examine a 1-year composite outcome (HF hospitalisation or mortality). Across BMI quartiles, higher BMI was associated with lower risk of the composite outcome (p(trend) <0.001). Contrastingly, higher WHtR was associated with higher risk of the composite outcome. Individuals in the lean-fat group, with low BMI and high WHtR (13.9%), were more likely to be women (35.4%) and to be from low-income countries (47.7%) (predominantly in South/Southeast Asia), and had higher prevalence of diabetes (46%), worse quality of life scores (63.3 +/- 24.2), and a higher rate of the composite outcome (51/232; 22%), compared to the other groups (p <0.05 for all). Following multivariable adjustment, the lean-fat group had higher adjusted risk of the composite outcome (hazard ratio 1.93, 95% CI 1.17-3.18, p = 0.01), compared to the obese-thin group, with high BMI and low WHtR. Results were consistent across both HF subtypes (HFpEF and HF with reduced ejection fraction [HFrEF]; p(interaction) = 0.355). Selection bias and residual confounding are potential limitations of such multinational observational registries. Conclusions In this cohort of Asian patients with HF, the 'obesity paradox' is observed only when defined using BMI, with WHtR showing the opposite association with the composite outcome. Lean-fat patients, with high WHtR and low BMI, have the worst outcomes. A direct correlation between high WHtR and the composite outcome is apparent in both HFpEF and HFrEF.

KW - BODY-MASS INDEX

KW - SUDDEN CARDIAC DEATH

KW - MORTALITY

KW - PARADOX

KW - METAANALYSIS

KW - ADIPOSITY

KW - RISK

KW - FAT

U2 - 10.1371/journal.pmed.1002916

DO - 10.1371/journal.pmed.1002916

M3 - Article

VL - 16

JO - PLOS MEDICINE

JF - PLOS MEDICINE

SN - 1549-1277

IS - 9

M1 - 1002916

ER -

ID: 101939064