Publication

Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies

Arbeev, K. G., Verhulst, S., Steenstrup, T., Kark, J. D., Bagley, O., Kooperberg, C., Reiner, A. P., Hwang, S-J., Levy, D., Fitzpatrick, A. L., Christensen, K., Yashin, A. I. & Aviv, A., 26-Feb-2020, In : Jama network open. 3, 2, 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Arbeev, K. G., Verhulst, S., Steenstrup, T., Kark, J. D., Bagley, O., Kooperberg, C., ... Aviv, A. (2020). Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies. Jama network open, 3(2). https://doi.org/10.1001/jamanetworkopen.2020.0023

Author

Arbeev, Konstantin G. ; Verhulst, Simon ; Steenstrup, Troels ; Kark, Jeremy D. ; Bagley, Olivia ; Kooperberg, Charles ; Reiner, Alexander P. ; Hwang, Shih-Jen ; Levy, Daniel ; Fitzpatrick, Annette L. ; Christensen, Kaare ; Yashin, Anatoliy I. ; Aviv, Abraham. / Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies. In: Jama network open. 2020 ; Vol. 3, No. 2.

Harvard

Arbeev, KG, Verhulst, S, Steenstrup, T, Kark, JD, Bagley, O, Kooperberg, C, Reiner, AP, Hwang, S-J, Levy, D, Fitzpatrick, AL, Christensen, K, Yashin, AI & Aviv, A 2020, 'Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies', Jama network open, vol. 3, no. 2. https://doi.org/10.1001/jamanetworkopen.2020.0023

Standard

Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies. / Arbeev, Konstantin G.; Verhulst, Simon; Steenstrup, Troels; Kark, Jeremy D.; Bagley, Olivia; Kooperberg, Charles; Reiner, Alexander P.; Hwang, Shih-Jen; Levy, Daniel; Fitzpatrick, Annette L.; Christensen, Kaare; Yashin, Anatoliy I.; Aviv, Abraham.

In: Jama network open, Vol. 3, No. 2, 26.02.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Arbeev KG, Verhulst S, Steenstrup T, Kark JD, Bagley O, Kooperberg C et al. Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies. Jama network open. 2020 Feb 26;3(2). https://doi.org/10.1001/jamanetworkopen.2020.0023


BibTeX

@article{b8ee9587bfc54d54866c450c5284159d,
title = "Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies",
abstract = "Importance Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span. Objective To examine whether LTL is associated with the life span of contemporary humans. Design, Setting, and Participants This cohort study included 3259 adults of European ancestry from the Cardiovascular Health Study (CHS), Framingham Heart Study (FHS), and Women's Health Initiative (WHI). Leukocyte telomere length was measured in 1992 and 1997 in the CHS, from 1995 to 1998 in the FHS, and from 1993 to 1998 in the WHI. Data analysis was conducted from February 2017 to December 2019. Main Outcomes and Measures Death and LTL, measured by Southern blots of the terminal restriction fragments, were the main outcomes. Cause of death was adjudicated by end point committees. Results The analyzed sample included 3259 participants (2342 [71.9{\%}] women), with a median (range) age of 69.0 (50.0-98.0) years at blood collection. The median (range) follow-up until death was 10.9 (0.2-23.0) years in CHS, 19.7 (3.4-23.0) years in FHS, and 16.6 (0.5-20.0) years in WHI. During follow-up, there were 1525 deaths (482 [31.6{\%}] of cardiovascular disease; 373 [24.5{\%}] of cancer, and 670 [43.9{\%}] of other or unknown causes). Short LTL, expressed in residual LTL, was associated with increased mortality risk. Overall, the hazard ratio for all-cause mortality for a 1-kilobase decrease in LTL was 1.34 (95{\%} CI, 1.21-1.47). This association was stronger for noncancer causes of death (cardiovascular death: hazard ratio, 1.28; 95{\%} CI, 1.08-1.52; cancer: hazard ratio, 1.13; 95{\%} CI, 0.93-1.36; and other causes: hazard ratio, 1.53; 95{\%} CI, 1.32-1.77). Conclusions and Relevance The results of this study indicate that LTL is associated with a natural life span limit in contemporary humans.Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length-associated mortality from noncancer causes increased as participants aged, approaching their age at death. Meaning These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.This cohort study examines whether leukocyte telomere length is associated with the life span of contemporary humans.",
keywords = "CARDIOVASCULAR-DISEASE, SURVIVAL, CANCER, LIMIT, RISK, METAANALYSIS, DEMOGRAPHY, DEATH",
author = "Arbeev, {Konstantin G.} and Simon Verhulst and Troels Steenstrup and Kark, {Jeremy D.} and Olivia Bagley and Charles Kooperberg and Reiner, {Alexander P.} and Shih-Jen Hwang and Daniel Levy and Fitzpatrick, {Annette L.} and Kaare Christensen and Yashin, {Anatoliy I.} and Abraham Aviv",
year = "2020",
month = "2",
day = "26",
doi = "10.1001/jamanetworkopen.2020.0023",
language = "English",
volume = "3",
journal = "Jama network open",
issn = "2574-3805",
publisher = "AMER MEDICAL ASSOC",
number = "2",

}

RIS

TY - JOUR

T1 - Association of leukocyte telomere length with mortality among adult participants in 3 longitudinal studies

AU - Arbeev, Konstantin G.

AU - Verhulst, Simon

AU - Steenstrup, Troels

AU - Kark, Jeremy D.

AU - Bagley, Olivia

AU - Kooperberg, Charles

AU - Reiner, Alexander P.

AU - Hwang, Shih-Jen

AU - Levy, Daniel

AU - Fitzpatrick, Annette L.

AU - Christensen, Kaare

AU - Yashin, Anatoliy I.

AU - Aviv, Abraham

PY - 2020/2/26

Y1 - 2020/2/26

N2 - Importance Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span. Objective To examine whether LTL is associated with the life span of contemporary humans. Design, Setting, and Participants This cohort study included 3259 adults of European ancestry from the Cardiovascular Health Study (CHS), Framingham Heart Study (FHS), and Women's Health Initiative (WHI). Leukocyte telomere length was measured in 1992 and 1997 in the CHS, from 1995 to 1998 in the FHS, and from 1993 to 1998 in the WHI. Data analysis was conducted from February 2017 to December 2019. Main Outcomes and Measures Death and LTL, measured by Southern blots of the terminal restriction fragments, were the main outcomes. Cause of death was adjudicated by end point committees. Results The analyzed sample included 3259 participants (2342 [71.9%] women), with a median (range) age of 69.0 (50.0-98.0) years at blood collection. The median (range) follow-up until death was 10.9 (0.2-23.0) years in CHS, 19.7 (3.4-23.0) years in FHS, and 16.6 (0.5-20.0) years in WHI. During follow-up, there were 1525 deaths (482 [31.6%] of cardiovascular disease; 373 [24.5%] of cancer, and 670 [43.9%] of other or unknown causes). Short LTL, expressed in residual LTL, was associated with increased mortality risk. Overall, the hazard ratio for all-cause mortality for a 1-kilobase decrease in LTL was 1.34 (95% CI, 1.21-1.47). This association was stronger for noncancer causes of death (cardiovascular death: hazard ratio, 1.28; 95% CI, 1.08-1.52; cancer: hazard ratio, 1.13; 95% CI, 0.93-1.36; and other causes: hazard ratio, 1.53; 95% CI, 1.32-1.77). Conclusions and Relevance The results of this study indicate that LTL is associated with a natural life span limit in contemporary humans.Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length-associated mortality from noncancer causes increased as participants aged, approaching their age at death. Meaning These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.This cohort study examines whether leukocyte telomere length is associated with the life span of contemporary humans.

AB - Importance Leukocyte telomere length (LTL) is a trait associated with risk of cardiovascular disease and cancer, the 2 major disease categories that largely define longevity in the United States. However, it remains unclear whether LTL is associated with the human life span. Objective To examine whether LTL is associated with the life span of contemporary humans. Design, Setting, and Participants This cohort study included 3259 adults of European ancestry from the Cardiovascular Health Study (CHS), Framingham Heart Study (FHS), and Women's Health Initiative (WHI). Leukocyte telomere length was measured in 1992 and 1997 in the CHS, from 1995 to 1998 in the FHS, and from 1993 to 1998 in the WHI. Data analysis was conducted from February 2017 to December 2019. Main Outcomes and Measures Death and LTL, measured by Southern blots of the terminal restriction fragments, were the main outcomes. Cause of death was adjudicated by end point committees. Results The analyzed sample included 3259 participants (2342 [71.9%] women), with a median (range) age of 69.0 (50.0-98.0) years at blood collection. The median (range) follow-up until death was 10.9 (0.2-23.0) years in CHS, 19.7 (3.4-23.0) years in FHS, and 16.6 (0.5-20.0) years in WHI. During follow-up, there were 1525 deaths (482 [31.6%] of cardiovascular disease; 373 [24.5%] of cancer, and 670 [43.9%] of other or unknown causes). Short LTL, expressed in residual LTL, was associated with increased mortality risk. Overall, the hazard ratio for all-cause mortality for a 1-kilobase decrease in LTL was 1.34 (95% CI, 1.21-1.47). This association was stronger for noncancer causes of death (cardiovascular death: hazard ratio, 1.28; 95% CI, 1.08-1.52; cancer: hazard ratio, 1.13; 95% CI, 0.93-1.36; and other causes: hazard ratio, 1.53; 95% CI, 1.32-1.77). Conclusions and Relevance The results of this study indicate that LTL is associated with a natural life span limit in contemporary humans.Question Is leukocyte telomere length associated with the natural life span of contemporary humans? Findings This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length-associated mortality from noncancer causes increased as participants aged, approaching their age at death. Meaning These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.This cohort study examines whether leukocyte telomere length is associated with the life span of contemporary humans.

KW - CARDIOVASCULAR-DISEASE

KW - SURVIVAL

KW - CANCER

KW - LIMIT

KW - RISK

KW - METAANALYSIS

KW - DEMOGRAPHY

KW - DEATH

U2 - 10.1001/jamanetworkopen.2020.0023

DO - 10.1001/jamanetworkopen.2020.0023

M3 - Article

VL - 3

JO - Jama network open

JF - Jama network open

SN - 2574-3805

IS - 2

ER -

ID: 120450194