Publication

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication

Vehof, J., Risselada, A. J., Al Hadithy, A. F. Y., Burger, H., Snieder, H., Wilffert, B., Arends, J., Wunderink, L., Knegtering, H., Wiersma, D., Cohen, D., Mulder, H. & Bruggeman, R., Jul-2011, In : Psychopharmacology. 216, 2, p. 257-265 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vehof, J., Risselada, A. J., Al Hadithy, A. F. Y., Burger, H., Snieder, H., Wilffert, B., ... Bruggeman, R. (2011). Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. Psychopharmacology, 216(2), 257-265. https://doi.org/10.1007/s00213-011-2211-x

Author

Vehof, Jelle ; Risselada, Arne J. ; Al Hadithy, Asmar F. Y. ; Burger, Huibert ; Snieder, Harold ; Wilffert, Bob ; Arends, Johan ; Wunderink, Lex ; Knegtering, Henrikus ; Wiersma, Durk ; Cohen, Dan ; Mulder, Hans ; Bruggeman, Richard. / Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. In: Psychopharmacology. 2011 ; Vol. 216, No. 2. pp. 257-265.

Harvard

Vehof, J, Risselada, AJ, Al Hadithy, AFY, Burger, H, Snieder, H, Wilffert, B, Arends, J, Wunderink, L, Knegtering, H, Wiersma, D, Cohen, D, Mulder, H & Bruggeman, R 2011, 'Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication', Psychopharmacology, vol. 216, no. 2, pp. 257-265. https://doi.org/10.1007/s00213-011-2211-x

Standard

Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. / Vehof, Jelle; Risselada, Arne J.; Al Hadithy, Asmar F. Y.; Burger, Huibert; Snieder, Harold; Wilffert, Bob; Arends, Johan; Wunderink, Lex; Knegtering, Henrikus; Wiersma, Durk; Cohen, Dan; Mulder, Hans; Bruggeman, Richard.

In: Psychopharmacology, Vol. 216, No. 2, 07.2011, p. 257-265.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vehof J, Risselada AJ, Al Hadithy AFY, Burger H, Snieder H, Wilffert B et al. Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication. Psychopharmacology. 2011 Jul;216(2):257-265. https://doi.org/10.1007/s00213-011-2211-x


BibTeX

@article{e54695dcf3134023812f3848ee3284ef,
title = "Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication",
abstract = "Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively.We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c).We included 430 Caucasian patients with a non-affective psychotic disorder using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were obesity and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, rs346074 and rs346070, and one SNP in the CHRM3 gene, rs3738435, were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor.A significant association of interaction between haplotype rs346074-rs346070 and BMI (p value 0.025) and obesity (p value 0.005) in patients using high-H1 affinity antipsychotics versus patients using low-H1 affinity antipsychotics was found. There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants.This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in patients with a psychotic disorder using antipsychotics. In future, genotyping of HRH1 variants may help predicting weight gain in patients using antipsychotics.",
keywords = "Antipsychotics, BMI, HbA1c, Schizophrenia, Polymorphism, Histamine, Muscarine, Pharmacogenetics, Weight gain, Hyperglycaemia, INDUCED WEIGHT-GAIN, DIABETES-MELLITUS, HAPLOTYPE RECONSTRUCTION, ATYPICAL ANTIPSYCHOTICS, PSYCHIATRIC-PATIENTS, GLUCOSE-HOMEOSTASIS, METABOLIC SYNDROME, PROMOTER REGION, 5-HT2C RECEPTOR, LEPTIN GENE",
author = "Jelle Vehof and Risselada, {Arne J.} and {Al Hadithy}, {Asmar F. Y.} and Huibert Burger and Harold Snieder and Bob Wilffert and Johan Arends and Lex Wunderink and Henrikus Knegtering and Durk Wiersma and Dan Cohen and Hans Mulder and Richard Bruggeman",
year = "2011",
month = "7",
doi = "10.1007/s00213-011-2211-x",
language = "English",
volume = "216",
pages = "257--265",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "SPRINGER",
number = "2",

}

RIS

TY - JOUR

T1 - Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication

AU - Vehof, Jelle

AU - Risselada, Arne J.

AU - Al Hadithy, Asmar F. Y.

AU - Burger, Huibert

AU - Snieder, Harold

AU - Wilffert, Bob

AU - Arends, Johan

AU - Wunderink, Lex

AU - Knegtering, Henrikus

AU - Wiersma, Durk

AU - Cohen, Dan

AU - Mulder, Hans

AU - Bruggeman, Richard

PY - 2011/7

Y1 - 2011/7

N2 - Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively.We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c).We included 430 Caucasian patients with a non-affective psychotic disorder using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were obesity and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, rs346074 and rs346070, and one SNP in the CHRM3 gene, rs3738435, were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor.A significant association of interaction between haplotype rs346074-rs346070 and BMI (p value 0.025) and obesity (p value 0.005) in patients using high-H1 affinity antipsychotics versus patients using low-H1 affinity antipsychotics was found. There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants.This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in patients with a psychotic disorder using antipsychotics. In future, genotyping of HRH1 variants may help predicting weight gain in patients using antipsychotics.

AB - Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively.We investigated polymorphisms of the histamine H1 (HRH1) and muscarinic acetylcholine receptor M3 (CHRM3) receptor genes for an association with body mass index (BMI) and glycated hemoglobin (HbA1c).We included 430 Caucasian patients with a non-affective psychotic disorder using antipsychotics for at least 3 months. Primary endpoints of the study were cross-sectionally measured BMI and HbA1c; secondary endpoints were obesity and hyperglycaemia. Two single-nucleotide polymorphisms (SNPs) in the HRH1 gene, rs346074 and rs346070, and one SNP in the CHRM3 gene, rs3738435, were genotyped. Our primary hypothesis in this study was an interaction between genotype on BMI and antipsychotic affinity for the H1 and M3 receptor.A significant association of interaction between haplotype rs346074-rs346070 and BMI (p value 0.025) and obesity (p value 0.005) in patients using high-H1 affinity antipsychotics versus patients using low-H1 affinity antipsychotics was found. There was no association of CHRM3 gene variant rs3738435 with BMI, and we observed no association with HbA1c or hyperglycaemia in any of the variants.This study, for the first time, demonstrates a significant association between HRH1 variants and BMI in patients with a psychotic disorder using antipsychotics. In future, genotyping of HRH1 variants may help predicting weight gain in patients using antipsychotics.

KW - Antipsychotics

KW - BMI

KW - HbA1c

KW - Schizophrenia

KW - Polymorphism

KW - Histamine

KW - Muscarine

KW - Pharmacogenetics

KW - Weight gain

KW - Hyperglycaemia

KW - INDUCED WEIGHT-GAIN

KW - DIABETES-MELLITUS

KW - HAPLOTYPE RECONSTRUCTION

KW - ATYPICAL ANTIPSYCHOTICS

KW - PSYCHIATRIC-PATIENTS

KW - GLUCOSE-HOMEOSTASIS

KW - METABOLIC SYNDROME

KW - PROMOTER REGION

KW - 5-HT2C RECEPTOR

KW - LEPTIN GENE

U2 - 10.1007/s00213-011-2211-x

DO - 10.1007/s00213-011-2211-x

M3 - Article

VL - 216

SP - 257

EP - 265

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -

ID: 5352953