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Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia

Fedorenko, O. Y., Paderina, D. Z., Loonen, A. J. M., Pozhidaev, I., Boiko, A. S., Kornetova, E. G., Bokhan, N. A., Wilffert, B. & Ivanova, S. A., 8-May-2020, In : Human Psychopharmacology. 35, 4, 8 p., 2737.

Research output: Contribution to journalArticleAcademicpeer-review

  • Olga Yu Fedorenko
  • Diana Z. Paderina
  • Anton J. M. Loonen
  • Ivan Pozhidaev
  • Anastasiia S. Boiko
  • Elena G. Kornetova
  • Nikolay A. Bokhan
  • Bob Wilffert
  • Svetlana A. Ivanova

Objective: Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic-induced HPRL. Methods: We recruited 446 patients with schizophrenia from among the Russian population of the Siberian region. The polymorphism rs2734849 in the ANKK1 gene was genotyped with The MassARRAY® Analyzer 4 by Agena Bioscience™, using the kit SEQUENOM Consumables iPLEXGold 384. Genotype and allele frequencies were compared between groups of schizophrenia patients with and without HPRL using the χ2 test. Results: A comparison between schizophrenia patients with and without HPRL revealed significantly higher frequency of the C allele of the polymorphic variant rs2734849 in the ANKK1 gene in patients with HPRL as compared to the patients without it (χ2 = 3.70; p =.05; odds ratio [OR] = 1.30 [0.99–1.69]). Conclusion: The functional polymorphism rs2734849 in the ANKK1 gene was associated with HPRL in patients with schizophrenia.

Original languageEnglish
Article number2737
Number of pages8
JournalHuman Psychopharmacology
Volume35
Issue number4
Publication statusPublished - 8-May-2020

    Keywords

  • ANKK1, hyperprolactinemia, polymorphism, schizophrenia, D2 RECEPTOR-BINDING, KINASE GENE, SCHIZOPHRENIA, DRD2, IDENTIFICATION, ACTIVATION, REGION, SUSCEPTIBILITY, REPEAT, CYP2D6

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