Publication

Assessment of the Broader Economic Consequences of HPV Prevention from a Government-Perspective: A Fiscal Analytic Approach

Setiawan, D., Kotsopoulos, N., Wilschut, J. C., Postma, M. J. & Connolly, M. P., 4-Aug-2016, In : PLoS ONE. 11, 8, 12 p., e0160707.

Research output: Contribution to journalArticleAcademicpeer-review

Background

Cervical cancer poses a substantial burden in terms of morbidity, mortality, and economic losses, especially in low/middle-income countries. HPV vaccination and/or cervical cancer screening among females may reduce the burden of HPV-related diseases, including cervical cancer. However, limited funds may impede the implementation of population-based programmes. Governmental investments in the prevention of infectious disease may have broader economic and fiscal benefits, which are not accounted in conventional economic analyses. This study estimates the broader economic and fiscal impacts of implementing HPV vaccination and/or cervical cancer screening in Indonesia from the perspective of the government.

Methods

A government-perspective quantitative analytic framework was applied to assess the Net Present Value (NPV) of investment on cervical cancer prevention strategies including HPV vaccination, cervical screening and its combination in Indonesia. All monetary values were presented in International Dollars (I$).

Results

Based on a cohort of 10,000,000 Indonesian 12-year-old females, it was estimated that HPV vaccination and/or cervical cancer screening result in a positive NPV for the Indonesian government. The combination of cervical screening and HPV vaccination generated a substantial reduction of cervical cancer incidence and HPV-related mortality of 87,862 and 19,359, respectively. It was estimated that HPV vaccination in combination with cervical screening is the most favorable option for cervical cancer prevention (NPV I $2.031.786.000), followed by HPV vaccination alone (NPV I$1.860.783.000) and cervical screening alone (NPV I$375.244.000).

Conclusion

In addition to clinical benefits, investing in HPV vaccination and cervical screening may yield considerable fiscal benefits for the Indonesian governments due to lifelong benefits resulting from reduction of cervical cancer-related morbidity and mortality.

Original languageEnglish
Article numbere0160707
Number of pages12
JournalPLoS ONE
Volume11
Issue number8
Publication statusPublished - 4-Aug-2016

    Keywords

  • CERVICAL-CANCER PREVENTION, HUMAN-PAPILLOMAVIRUS VACCINATION, COST-EFFECTIVENESS, AS04-ADJUVANTED VACCINE, QUADRIVALENT VACCINE, THAILAND, HEALTH, TRIAL, STRATEGIES, MORTALITY
Related Datasets
  1. Data from: Assessment of the broader economic consequences of HPV prevention from a government-perspective: a fiscal analytic approach

    Setiawan, D. (Creator), Kotsopoulos, N. (Creator), Wilschut, J. (Creator), Postma, M. (Creator) & Connolly, M. (Creator), University of Groningen, 13-Sep-2016

    Dataset

View all (1) »

Download statistics

No data available

ID: 34638759