Publication

Aspirin treatment of the low-dose-endotoxin-treated pregnant rat: Pathophysiologic and immunohistologic aspects

Faas, MM., Schuiling, GA., Baller, JFW., Valkhof, N. & Bakker, WW., Nov-1997, In : Journal of Laboratory and Clinical Medicine. 130, 5, p. 496-508 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • MM Faas
  • GA Schuiling
  • JFW Baller
  • N Valkhof
  • WW Bakker

In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular inflammation in pregnant rats infused with low-dose endotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endotoxin (ET rats) or saline (control rats) and received ASA in their drinking water. These rats were compared with non-ASA-treated rats. Blood pressure and albumin excretion were measured from day 15 to day 21, and glomerular fibrinogen and ecto-ADPase activity were measured at day 21. Glomerular inflammation was evaluated at various times after the start of the infusion. The results show that treatment with ASA had a significant beneficial effect on hypertension and inflammation induced by endotoxin in pregnant rats, whereas it reduced albumin excretion and glomerular fibrinogen deposits in some of the rats.

Original languageEnglish
Pages (from-to)496-508
Number of pages13
JournalJournal of Laboratory and Clinical Medicine
Volume130
Issue number5
Publication statusPublished - Nov-1997

    Keywords

  • HUMAN-ENDOTHELIAL-CELLS, PROSTAGLANDIN ENDOPEROXIDES, PLATELET-AGGREGATION, INFUSION, GLOMERULONEPHRITIS, PREECLAMPSIA, INFLAMMATION, ADHESION

ID: 6536185