Aspirin treatment of the low-dose-endotoxin-treated pregnant rat: Pathophysiologic and immunohistologic aspectsFaas, MM., Schuiling, GA., Baller, JFW., Valkhof, N. & Bakker, WW., Nov-1997, In : Journal of Laboratory and Clinical Medicine. 130, 5, p. 496-508 13 p.
Research output: Contribution to journal › Article › Academic › peer-review
In the present study, we evaluated the effect of low-dose aspirin (acetylsalicylic acid (ASA); 1.0 mg/kg daily) on blood pressure, albumin excretion, glomerular fibrinogen deposits, and glomerular (basement) membrane-bound adenosine diphosphatase (ecto-ADPase) activity, as well as on glomerular inflammation in pregnant rats infused with low-dose endotoxin (1.0 mg/kg). Rats (day 14 of pregnancy) were infused with endotoxin (ET rats) or saline (control rats) and received ASA in their drinking water. These rats were compared with non-ASA-treated rats. Blood pressure and albumin excretion were measured from day 15 to day 21, and glomerular fibrinogen and ecto-ADPase activity were measured at day 21. Glomerular inflammation was evaluated at various times after the start of the infusion. The results show that treatment with ASA had a significant beneficial effect on hypertension and inflammation induced by endotoxin in pregnant rats, whereas it reduced albumin excretion and glomerular fibrinogen deposits in some of the rats.
|Number of pages||13|
|Journal||Journal of Laboratory and Clinical Medicine|
|Publication status||Published - Nov-1997|
- HUMAN-ENDOTHELIAL-CELLS, PROSTAGLANDIN ENDOPEROXIDES, PLATELET-AGGREGATION, INFUSION, GLOMERULONEPHRITIS, PREECLAMPSIA, INFLAMMATION, ADHESION