Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics

Quan, K., Zhang, Z., Chen, H., Ren, X., Ren, Y., Peterson, B. W., van der Mei, H. C. & Busscher, H. J., 6-Aug-2019, In : Small. 6 p., 1902313.

Research output: Contribution to journalArticleAcademicpeer-review

The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic-iron-oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4-6-fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.

Original languageEnglish
Article number1902313
Number of pages6
Publication statusE-pub ahead of print - 6-Aug-2019


  • antibiotic penetration, biofilm channels, biofilm eradication, gentamicin, iron-oxide nanoparticles, GENTAMICIN, RELEASE

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