ArgO145, a Stx2a prophage of a bovine O145: H-STEC strain, is closely related to phages of virulent human strainsKrüger, A., Burgán, J., Friedrich, A. W., Jwa, R. & Pma, L., Jun-2018, In : Infection genetics and evolution. 60, p. 126-132 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Shiga toxins (Stx) are the main virulence factor of a pathogroup of Escherichia coli strains that cause severe human diseases. These toxins are encoded in prophages (Stx prophages), and generally their expression depends on prophage induction. Several studies have reported high diversity among both Stx prophages and Stx. In particular, the toxin subtype Stx2a is associated with high virulence and HUS. Here, we report the genome of ArgO145, an inducible Stx2a prophage identified in a bovine O145: H- strain which produced high levels of Shiga toxin and Stx phage particles. The ArgO145 genome shared lambda phage organization, with recombination, regulation, replication, lysis, and head and tail structural gene regions, although some lambda genes encoding regulatory proteins could not be identified. Remarkably, some Stx2a phages of strains isolated from patients in other countries showed high similarity to ArgO145.
|Number of pages||7|
|Journal||Infection genetics and evolution|
|Publication status||Published - Jun-2018|
- Stx-converting phages, Shiga toxin-producing Escherichia coli, O145:H-, ESCHERICHIA-COLI O157-H7, GENETIC-DIVERSITY, ACID RESISTANCE, EXPRESSION, VARIANTS, BACTERIOPHAGES, INFECTIONS, ASSOCIATION, GENOMES, O157H7