Publication

Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage: risk factors for presence of aneurysms and diagnostic yield of imaging

Bakker, N. A., Groen, R. J. M., Foumani, M., Uyttenboogaart, M., Eshghi, O. S., Metzemaekers, J., Luijckx, G. J. & van Dijk, J. M. C., Aug-2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 8, p. 883-886 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Bakker, N. A., Groen, R. J. M., Foumani, M., Uyttenboogaart, M., Eshghi, O. S., Metzemaekers, J., Luijckx, G. J., & van Dijk, J. M. C. (2014). Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage: risk factors for presence of aneurysms and diagnostic yield of imaging. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 883-886. https://doi.org/10.1136/jnnp-2013-305955

Author

Bakker, Nicolaas A. ; Groen, Rob J. M. ; Foumani, Mahrouz ; Uyttenboogaart, Maarten ; Eshghi, Omid S. ; Metzemaekers, Joannes ; Luijckx, Gert Jan ; van Dijk, J. Marc C. / Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage : risk factors for presence of aneurysms and diagnostic yield of imaging. In: Journal of Neurology, Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 8. pp. 883-886.

Harvard

Bakker, NA, Groen, RJM, Foumani, M, Uyttenboogaart, M, Eshghi, OS, Metzemaekers, J, Luijckx, GJ & van Dijk, JMC 2014, 'Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage: risk factors for presence of aneurysms and diagnostic yield of imaging', Journal of Neurology, Neurosurgery and Psychiatry, vol. 85, no. 8, pp. 883-886. https://doi.org/10.1136/jnnp-2013-305955

Standard

Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage : risk factors for presence of aneurysms and diagnostic yield of imaging. / Bakker, Nicolaas A.; Groen, Rob J. M.; Foumani, Mahrouz; Uyttenboogaart, Maarten; Eshghi, Omid S.; Metzemaekers, Joannes; Luijckx, Gert Jan; van Dijk, J. Marc C.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 85, No. 8, 08.2014, p. 883-886.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Bakker NA, Groen RJM, Foumani M, Uyttenboogaart M, Eshghi OS, Metzemaekers J et al. Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage: risk factors for presence of aneurysms and diagnostic yield of imaging. Journal of Neurology, Neurosurgery and Psychiatry. 2014 Aug;85(8):883-886. https://doi.org/10.1136/jnnp-2013-305955


BibTeX

@article{f4d0eecccc0f46d5a5c99ec2b754fe2a,
title = "Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage: risk factors for presence of aneurysms and diagnostic yield of imaging",
abstract = "OBJECTIVE: Patients without a subarachnoid haemorrhage (SAH) on brain CT scan (CT-negative), but a lumbar puncture (LP)-proven SAH, are a challenging patient category. The optimal diagnostic approach is still a matter of debate. Also, there is little knowledge on the probability of finding an underlying vascular lesion.DESIGN: In this observational study, a consecutive cohort of 94 patients with CT-negative, LP-positive SAH was prospectively collected between 1998 and 2013. The yield of diagnostic modalities as well as patient outcome was studied. In addition, risk factors for the presence of a vascular lesion were analysed.RESULTS: In 40 patients (43%), an intracranial vascular abnormality was detected: 37 aneurysms and three arterial dissections. Female gender was significantly associated with detection of a vascular lesion. Time between ictus and diagnosis of SAH was not associated with the presence of vascular pathology. Overall, 99% of patients had a modified Rankin Score of 0-2 after a median follow-up of 72 months. The yield of additional digital subtraction angiography in patients with a negative CT angiography was zero.CONCLUSIONS: In this study, the chance of finding a vascular lesion in a patient with CT-negative, LP-positive SAH was 43%, underlining the need for an adequate diagnostic workup. In general, the patient outcome was favourable. Female gender was found to be predictive for detecting a vascular lesion. In contrast with previous reports, the interval between ictus and LP was not associated with the presence of an aneurysm.",
keywords = "COMPUTED-TOMOGRAPHY, CEREBRAL-ANGIOGRAPHY, SCAN, METAANALYSIS",
author = "Bakker, {Nicolaas A.} and Groen, {Rob J. M.} and Mahrouz Foumani and Maarten Uyttenboogaart and Eshghi, {Omid S.} and Joannes Metzemaekers and Luijckx, {Gert Jan} and {van Dijk}, {J. Marc C.}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2014",
month = aug,
doi = "10.1136/jnnp-2013-305955",
language = "English",
volume = "85",
pages = "883--886",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "1468-330X",
publisher = "BMJ PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Appreciation of CT-negative, lumbar puncture-positive subarachnoid haemorrhage

T2 - risk factors for presence of aneurysms and diagnostic yield of imaging

AU - Bakker, Nicolaas A.

AU - Groen, Rob J. M.

AU - Foumani, Mahrouz

AU - Uyttenboogaart, Maarten

AU - Eshghi, Omid S.

AU - Metzemaekers, Joannes

AU - Luijckx, Gert Jan

AU - van Dijk, J. Marc C.

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/8

Y1 - 2014/8

N2 - OBJECTIVE: Patients without a subarachnoid haemorrhage (SAH) on brain CT scan (CT-negative), but a lumbar puncture (LP)-proven SAH, are a challenging patient category. The optimal diagnostic approach is still a matter of debate. Also, there is little knowledge on the probability of finding an underlying vascular lesion.DESIGN: In this observational study, a consecutive cohort of 94 patients with CT-negative, LP-positive SAH was prospectively collected between 1998 and 2013. The yield of diagnostic modalities as well as patient outcome was studied. In addition, risk factors for the presence of a vascular lesion were analysed.RESULTS: In 40 patients (43%), an intracranial vascular abnormality was detected: 37 aneurysms and three arterial dissections. Female gender was significantly associated with detection of a vascular lesion. Time between ictus and diagnosis of SAH was not associated with the presence of vascular pathology. Overall, 99% of patients had a modified Rankin Score of 0-2 after a median follow-up of 72 months. The yield of additional digital subtraction angiography in patients with a negative CT angiography was zero.CONCLUSIONS: In this study, the chance of finding a vascular lesion in a patient with CT-negative, LP-positive SAH was 43%, underlining the need for an adequate diagnostic workup. In general, the patient outcome was favourable. Female gender was found to be predictive for detecting a vascular lesion. In contrast with previous reports, the interval between ictus and LP was not associated with the presence of an aneurysm.

AB - OBJECTIVE: Patients without a subarachnoid haemorrhage (SAH) on brain CT scan (CT-negative), but a lumbar puncture (LP)-proven SAH, are a challenging patient category. The optimal diagnostic approach is still a matter of debate. Also, there is little knowledge on the probability of finding an underlying vascular lesion.DESIGN: In this observational study, a consecutive cohort of 94 patients with CT-negative, LP-positive SAH was prospectively collected between 1998 and 2013. The yield of diagnostic modalities as well as patient outcome was studied. In addition, risk factors for the presence of a vascular lesion were analysed.RESULTS: In 40 patients (43%), an intracranial vascular abnormality was detected: 37 aneurysms and three arterial dissections. Female gender was significantly associated with detection of a vascular lesion. Time between ictus and diagnosis of SAH was not associated with the presence of vascular pathology. Overall, 99% of patients had a modified Rankin Score of 0-2 after a median follow-up of 72 months. The yield of additional digital subtraction angiography in patients with a negative CT angiography was zero.CONCLUSIONS: In this study, the chance of finding a vascular lesion in a patient with CT-negative, LP-positive SAH was 43%, underlining the need for an adequate diagnostic workup. In general, the patient outcome was favourable. Female gender was found to be predictive for detecting a vascular lesion. In contrast with previous reports, the interval between ictus and LP was not associated with the presence of an aneurysm.

KW - COMPUTED-TOMOGRAPHY

KW - CEREBRAL-ANGIOGRAPHY

KW - SCAN

KW - METAANALYSIS

U2 - 10.1136/jnnp-2013-305955

DO - 10.1136/jnnp-2013-305955

M3 - Article

C2 - 24357683

VL - 85

SP - 883

EP - 886

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 1468-330X

IS - 8

ER -

ID: 13587820