Publication

Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium

Ruifrok, W. T., Westenbrink, B. D., de Boer, R. A., den Hamer, I. J., Erasmus, M. E., Mungroop, H. E., Epema, A. H., Voors, A. A., van Veldhuisen, D. J. & van Gilst, W. H., May-2010, In : Netherlands Heart Journal. 18, 5, p. 236-242 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Ruifrok, W. T., Westenbrink, B. D., de Boer, R. A., den Hamer, I. J., Erasmus, M. E., Mungroop, H. E., Epema, A. H., Voors, A. A., van Veldhuisen, D. J., & van Gilst, W. H. (2010). Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium. Netherlands Heart Journal, 18(5), 236-242.

Author

Ruifrok, W. T. ; Westenbrink, B. D. ; de Boer, R. A. ; den Hamer, I. J. ; Erasmus, M. E. ; Mungroop, H. E. ; Epema, A. H. ; Voors, A. A. ; van Veldhuisen, D. J. ; van Gilst, W. H. / Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium. In: Netherlands Heart Journal. 2010 ; Vol. 18, No. 5. pp. 236-242.

Harvard

Ruifrok, WT, Westenbrink, BD, de Boer, RA, den Hamer, IJ, Erasmus, ME, Mungroop, HE, Epema, AH, Voors, AA, van Veldhuisen, DJ & van Gilst, WH 2010, 'Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium', Netherlands Heart Journal, vol. 18, no. 5, pp. 236-242.

Standard

Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium. / Ruifrok, W. T.; Westenbrink, B. D.; de Boer, R. A.; den Hamer, I. J.; Erasmus, M. E.; Mungroop, H. E.; Epema, A. H.; Voors, A. A.; van Veldhuisen, D. J.; van Gilst, W. H.

In: Netherlands Heart Journal, Vol. 18, No. 5, 05.2010, p. 236-242.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Ruifrok WT, Westenbrink BD, de Boer RA, den Hamer IJ, Erasmus ME, Mungroop HE et al. Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium. Netherlands Heart Journal. 2010 May;18(5):236-242.


BibTeX

@article{98651c1aa21d40f48bcc46620385a4ab,
title = "Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium",
abstract = "Objectives. We aimed to compare the rate of apoptosis after cardiopulmonary bypass (CPB) and cardioplegic arrest during coronary artery bypass grafting (CABG) surgery between atrial and ventricular tissue.Methods. During CABG surgery with CPB and cardioplegic arrest, sequential biopsies were taken from the right atrial appendage and left ventricular anterior wall before CPB and after aortic cross clamp release. Change in number of apoptotic cells and biochemical markers of myocardial ischaemia and renal dysfunction were assessed.Results. CPB was associated with a transient small, but significant increase in CK (1091 +/- 374%), CK-MB (128 +/- 38%), troponin-T (102 +/- 13%) and NT-proBNP (1308 +/- 372%) levels (all: pConclusion. CABG surgery with CPB and cardioplegic arrest is associated with an elevated rate of apoptosis in ventricular but not in atrial myocardial tissue. Ventricular tissue may be more sensitive to detect changes than atrial tissue, and may be more useful to investigate the protective effects of therapeutic intervention. (Neth Heart J 2010;18:236-42.)",
keywords = "Coronary Artery Bypass, Apoptosis, Heart Ventricules, Heart Arrest, Heart Atria, Reperfusion Injury, REACTIVE OXYGEN, CARDIAC-SURGERY, ERYTHROPOIETIN PROTECTS, REPERFUSION INJURY, ISCHEMIA, HEART, CARDIOPROTECTION, MECHANISMS, MYOCYTES, PATHWAY",
author = "Ruifrok, {W. T.} and Westenbrink, {B. D.} and {de Boer}, {R. A.} and {den Hamer}, {I. J.} and Erasmus, {M. E.} and Mungroop, {H. E.} and Epema, {A. H.} and Voors, {A. A.} and {van Veldhuisen}, {D. J.} and {van Gilst}, {W. H.}",
year = "2010",
month = may,
language = "English",
volume = "18",
pages = "236--242",
journal = "Netherlands Heart Journal",
issn = "0929-7456",
publisher = "Bohn, Stafleu, Van Loghum",
number = "5",

}

RIS

TY - JOUR

T1 - Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium

AU - Ruifrok, W. T.

AU - Westenbrink, B. D.

AU - de Boer, R. A.

AU - den Hamer, I. J.

AU - Erasmus, M. E.

AU - Mungroop, H. E.

AU - Epema, A. H.

AU - Voors, A. A.

AU - van Veldhuisen, D. J.

AU - van Gilst, W. H.

PY - 2010/5

Y1 - 2010/5

N2 - Objectives. We aimed to compare the rate of apoptosis after cardiopulmonary bypass (CPB) and cardioplegic arrest during coronary artery bypass grafting (CABG) surgery between atrial and ventricular tissue.Methods. During CABG surgery with CPB and cardioplegic arrest, sequential biopsies were taken from the right atrial appendage and left ventricular anterior wall before CPB and after aortic cross clamp release. Change in number of apoptotic cells and biochemical markers of myocardial ischaemia and renal dysfunction were assessed.Results. CPB was associated with a transient small, but significant increase in CK (1091 +/- 374%), CK-MB (128 +/- 38%), troponin-T (102 +/- 13%) and NT-proBNP (1308 +/- 372%) levels (all: pConclusion. CABG surgery with CPB and cardioplegic arrest is associated with an elevated rate of apoptosis in ventricular but not in atrial myocardial tissue. Ventricular tissue may be more sensitive to detect changes than atrial tissue, and may be more useful to investigate the protective effects of therapeutic intervention. (Neth Heart J 2010;18:236-42.)

AB - Objectives. We aimed to compare the rate of apoptosis after cardiopulmonary bypass (CPB) and cardioplegic arrest during coronary artery bypass grafting (CABG) surgery between atrial and ventricular tissue.Methods. During CABG surgery with CPB and cardioplegic arrest, sequential biopsies were taken from the right atrial appendage and left ventricular anterior wall before CPB and after aortic cross clamp release. Change in number of apoptotic cells and biochemical markers of myocardial ischaemia and renal dysfunction were assessed.Results. CPB was associated with a transient small, but significant increase in CK (1091 +/- 374%), CK-MB (128 +/- 38%), troponin-T (102 +/- 13%) and NT-proBNP (1308 +/- 372%) levels (all: pConclusion. CABG surgery with CPB and cardioplegic arrest is associated with an elevated rate of apoptosis in ventricular but not in atrial myocardial tissue. Ventricular tissue may be more sensitive to detect changes than atrial tissue, and may be more useful to investigate the protective effects of therapeutic intervention. (Neth Heart J 2010;18:236-42.)

KW - Coronary Artery Bypass

KW - Apoptosis

KW - Heart Ventricules

KW - Heart Arrest

KW - Heart Atria

KW - Reperfusion Injury

KW - REACTIVE OXYGEN

KW - CARDIAC-SURGERY

KW - ERYTHROPOIETIN PROTECTS

KW - REPERFUSION INJURY

KW - ISCHEMIA

KW - HEART

KW - CARDIOPROTECTION

KW - MECHANISMS

KW - MYOCYTES

KW - PATHWAY

M3 - Article

VL - 18

SP - 236

EP - 242

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

SN - 0929-7456

IS - 5

ER -

ID: 5097161