Publication

Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium

Ruifrok, W. T., Westenbrink, B. D., de Boer, R. A., den Hamer, I. J., Erasmus, M. E., Mungroop, H. E., Epema, A. H., Voors, A. A., van Veldhuisen, D. J. & van Gilst, W. H., May-2010, In : Netherlands Heart Journal. 18, 5, p. 236-242 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Objectives. We aimed to compare the rate of apoptosis after cardiopulmonary bypass (CPB) and cardioplegic arrest during coronary artery bypass grafting (CABG) surgery between atrial and ventricular tissue.

Methods. During CABG surgery with CPB and cardioplegic arrest, sequential biopsies were taken from the right atrial appendage and left ventricular anterior wall before CPB and after aortic cross clamp release. Change in number of apoptotic cells and biochemical markers of myocardial ischaemia and renal dysfunction were assessed.

Results. CPB was associated with a transient small, but significant increase in CK (1091 +/- 374%), CK-MB (128 +/- 38%), troponin-T (102 +/- 13%) and NT-proBNP (1308 +/- 372%) levels (all: p

Conclusion. CABG surgery with CPB and cardioplegic arrest is associated with an elevated rate of apoptosis in ventricular but not in atrial myocardial tissue. Ventricular tissue may be more sensitive to detect changes than atrial tissue, and may be more useful to investigate the protective effects of therapeutic intervention. (Neth Heart J 2010;18:236-42.)

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalNetherlands Heart Journal
Volume18
Issue number5
Publication statusPublished - May-2010

    Keywords

  • Coronary Artery Bypass, Apoptosis, Heart Ventricules, Heart Arrest, Heart Atria, Reperfusion Injury, REACTIVE OXYGEN, CARDIAC-SURGERY, ERYTHROPOIETIN PROTECTS, REPERFUSION INJURY, ISCHEMIA, HEART, CARDIOPROTECTION, MECHANISMS, MYOCYTES, PATHWAY

ID: 5097161