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Anxiety disorders and CRP in a population cohort study with 54326 participants: The LifeLines study

Naudé, P. J. W., Roest, A. M., Stein, D. J., de Jonge, P. & Doornbos, B., 2018, In : The World Journal of Biological Psychiatry. 19, 6, p. 461-470 10 p.

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  • Anxiety disorders and CRP in a population cohort study

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DOI

Objectives - Growing evidence indicates that inflammatory processes may play a role in the pathogenesis of anxiety disorders. Nevertheless, much remains to be learned about the involvement of inflammation, including C-reactive protein (CRP), in specific anxiety disorders. This study examines the relation between anxiety disorders and CRP. Methods - Associations of serum CRP with anxiety disorders were determined in a large population study (n = 54,326 participants, mean age = 47 years; 59% female), the LifeLines cohort. Depressive and anxiety disorders (generalized anxiety disorder, social anxiety phobia, panic disorder with or without agoraphobia and agoraphobia without panic disorder) were assessed using the Mini-International Neuropsychiatric Interview. Results - Anxiety disorders, with the exception of social anxiety disorder, were significantly associated with increased CRP. After adjusting for demographics, life-style factors, health factors, medication use, depression, and psychological stressors, CRP remained significantly associated with panic disorder with agoraphobia (beta = 0.01, p = 0.013). Moreover, CRP levels were significantly higher in people with panic disorder with agoraphobia compared to other anxiety disorders, independent of all covariates (F = 3.00, df = 4, p = 0.021). Conclusions - Panic disorder with agoraphobia is associated with increased CRP, although the effect size of this association is small. This indicates that neuroinflammatory mechanisms may play a potential role in its pathophysiology.

Original languageEnglish
Pages (from-to)461-470
Number of pages10
JournalThe World Journal of Biological Psychiatry
Volume19
Issue number6
Early online date29-Jan-2018
Publication statusPublished - 2018

    Keywords

  • Generalized anxiety disorder, social anxiety disorder, panic disorder, inflammation, agoraphobia, C-REACTIVE PROTEIN, NATIONAL COMORBIDITY SURVEY, MAJOR DEPRESSIVE DISORDER, PANIC DISORDER, GENERALIZED ANXIETY, PSYCHIATRIC COMORBIDITY, THREATENING EXPERIENCES, POSTTRAUMATIC-STRESS, RISK-FACTORS, LIFE EVENTS
Related Datasets
  1. Lifelines Biobank

    Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbuttel, B. (Creator), Stolk, R. (Creator), Zon, van, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), Boer, de, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), Dijk, van, F. (Creator), Lifelines, 2006

    Dataset

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ID: 53805168