Publication

Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys

Roke, Y., van Harten, P. N., Buitelaar, J. K., Tenback, D. E., de Rijke, Y. B. & Boot, A. M., 2012, In : Hormone Research in Paediatrics. 77, 4, p. 235-240 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Roke, Y., van Harten, P. N., Buitelaar, J. K., Tenback, D. E., de Rijke, Y. B., & Boot, A. M. (2012). Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys. Hormone Research in Paediatrics, 77(4), 235-240. https://doi.org/10.1159/000337910

Author

Roke, Yvette ; van Harten, Peter N. ; Buitelaar, Jan K. ; Tenback, Diederik E. ; de Rijke, Yolanda B. ; Boot, Annemieke M. / Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys. In: Hormone Research in Paediatrics. 2012 ; Vol. 77, No. 4. pp. 235-240.

Harvard

Roke, Y, van Harten, PN, Buitelaar, JK, Tenback, DE, de Rijke, YB & Boot, AM 2012, 'Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys' Hormone Research in Paediatrics, vol. 77, no. 4, pp. 235-240. https://doi.org/10.1159/000337910

Standard

Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys. / Roke, Yvette; van Harten, Peter N.; Buitelaar, Jan K.; Tenback, Diederik E.; de Rijke, Yolanda B.; Boot, Annemieke M.

In: Hormone Research in Paediatrics, Vol. 77, No. 4, 2012, p. 235-240.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Roke Y, van Harten PN, Buitelaar JK, Tenback DE, de Rijke YB, Boot AM. Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys. Hormone Research in Paediatrics. 2012;77(4):235-240. https://doi.org/10.1159/000337910


BibTeX

@article{f6db4311513843a799b78f1ccd8c8c61,
title = "Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys",
abstract = "Aims: This cross-sectional study investigates the effect of antipsychotic (AP)-induced hyperprolactinemia on testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, and puberty in boys with mainly autism spectrum disorders (ASD). Method: One hundred and four physically healthy 10- to 19-year-old boys with ASD or disruptive behavior disorder (DBD) were recruited between October 2006 and November 2009. Fifty-six adolescents had been treated with AP for >16 months; 48 had never been exposed to AP. Morning non-fasting levels of serum prolactin, testosterone, LH, FSH and inhibin B were obtained and Tanner pubertal stage was determined. Patients with hyperprolactinemia (n = 28) were compared to those without hyperprolactinemia (n = 76) using non-parametric or parametric tests, as appropriate. Results: Patients with AP-induced hyperprolactinemia had significantly lower testosterone levels with adjustment for age (p = 0.035) compared to patients without hyperprolactinemia and without AP treatment. The difference was not significant within the AP-treated group, and the level of testosterone was within the reference range compared to age- and gender-matched normative data. There was no between-group difference for LH, FSH, inhibin B or Tanner stages. Conclusion: AP-induced hyperprolactinemia is related to significantly lower testosterone levels in pubertal boys with ASD and DBD. Copyright (C) 2012 S. Karger AG, Basel",
keywords = "Hyperprolactinemia, Adolescents, Testosterone, Puberty, Antipsychotics, PERVASIVE DEVELOPMENTAL DISORDERS, SELF-ASSESSMENT, ATYPICAL ANTIPSYCHOTICS, SEXUAL-MATURATION, CHILDREN, RISPERIDONE, ADOLESCENTS, MEDICATION, SCHIZOPHRENIA, RELIABILITY",
author = "Yvette Roke and {van Harten}, {Peter N.} and Buitelaar, {Jan K.} and Tenback, {Diederik E.} and {de Rijke}, {Yolanda B.} and Boot, {Annemieke M.}",
year = "2012",
doi = "10.1159/000337910",
language = "English",
volume = "77",
pages = "235--240",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "KARGER",
number = "4",

}

RIS

TY - JOUR

T1 - Antipsychotic-Induced Hyperprolactinemia and Testosterone Levels in Boys

AU - Roke, Yvette

AU - van Harten, Peter N.

AU - Buitelaar, Jan K.

AU - Tenback, Diederik E.

AU - de Rijke, Yolanda B.

AU - Boot, Annemieke M.

PY - 2012

Y1 - 2012

N2 - Aims: This cross-sectional study investigates the effect of antipsychotic (AP)-induced hyperprolactinemia on testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, and puberty in boys with mainly autism spectrum disorders (ASD). Method: One hundred and four physically healthy 10- to 19-year-old boys with ASD or disruptive behavior disorder (DBD) were recruited between October 2006 and November 2009. Fifty-six adolescents had been treated with AP for >16 months; 48 had never been exposed to AP. Morning non-fasting levels of serum prolactin, testosterone, LH, FSH and inhibin B were obtained and Tanner pubertal stage was determined. Patients with hyperprolactinemia (n = 28) were compared to those without hyperprolactinemia (n = 76) using non-parametric or parametric tests, as appropriate. Results: Patients with AP-induced hyperprolactinemia had significantly lower testosterone levels with adjustment for age (p = 0.035) compared to patients without hyperprolactinemia and without AP treatment. The difference was not significant within the AP-treated group, and the level of testosterone was within the reference range compared to age- and gender-matched normative data. There was no between-group difference for LH, FSH, inhibin B or Tanner stages. Conclusion: AP-induced hyperprolactinemia is related to significantly lower testosterone levels in pubertal boys with ASD and DBD. Copyright (C) 2012 S. Karger AG, Basel

AB - Aims: This cross-sectional study investigates the effect of antipsychotic (AP)-induced hyperprolactinemia on testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, and puberty in boys with mainly autism spectrum disorders (ASD). Method: One hundred and four physically healthy 10- to 19-year-old boys with ASD or disruptive behavior disorder (DBD) were recruited between October 2006 and November 2009. Fifty-six adolescents had been treated with AP for >16 months; 48 had never been exposed to AP. Morning non-fasting levels of serum prolactin, testosterone, LH, FSH and inhibin B were obtained and Tanner pubertal stage was determined. Patients with hyperprolactinemia (n = 28) were compared to those without hyperprolactinemia (n = 76) using non-parametric or parametric tests, as appropriate. Results: Patients with AP-induced hyperprolactinemia had significantly lower testosterone levels with adjustment for age (p = 0.035) compared to patients without hyperprolactinemia and without AP treatment. The difference was not significant within the AP-treated group, and the level of testosterone was within the reference range compared to age- and gender-matched normative data. There was no between-group difference for LH, FSH, inhibin B or Tanner stages. Conclusion: AP-induced hyperprolactinemia is related to significantly lower testosterone levels in pubertal boys with ASD and DBD. Copyright (C) 2012 S. Karger AG, Basel

KW - Hyperprolactinemia

KW - Adolescents

KW - Testosterone

KW - Puberty

KW - Antipsychotics

KW - PERVASIVE DEVELOPMENTAL DISORDERS

KW - SELF-ASSESSMENT

KW - ATYPICAL ANTIPSYCHOTICS

KW - SEXUAL-MATURATION

KW - CHILDREN

KW - RISPERIDONE

KW - ADOLESCENTS

KW - MEDICATION

KW - SCHIZOPHRENIA

KW - RELIABILITY

U2 - 10.1159/000337910

DO - 10.1159/000337910

M3 - Article

VL - 77

SP - 235

EP - 240

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 4

ER -

ID: 5596436