Publication

Anti-neutrophil cytoplasmic autoantibodies and leukocyte-endothelial interactions: a sticky connection?

Heeringa, P., Huugen, D. & Tervaert, JWC., Nov-2005, In : TRENDS IN IMMUNOLOGY. 26, 11, p. 561-564 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Anti-neutrophil cytoplasmic autoantibodies (ANCA) with specificity for myeloperoxidase (MPO) or proteinase 3 (Pr3) are associated with systemic small-vessel vasculitides (SVV). Detection of ANCA is an established clinical tool in disease diagnosis and monitoring. Based on clinical and in vitro experimental evidence, a pathogenic role for ANCA has long been suspected, however, in vivo models in which causality can be tested have been lacking. Recently, an exciting novel rat model of MPO-ANCA-associated vasculitis has been described, which provides compelling evidence that MPO-ANCA are a primary pathogenic factor in SVV by augmenting leukocyte-endothelial interactions and vascular wall damage.

Original languageEnglish
Pages (from-to)561-564
Number of pages4
JournalTRENDS IN IMMUNOLOGY
Volume26
Issue number11
Publication statusPublished - Nov-2005

    Keywords

  • SYSTEMIC VASCULITIS, NEUTROPHILS, MYELOPEROXIDASE, ANTIBODIES, GLOMERULONEPHRITIS, PROTEINASE-3, GRANULOMATOSIS, ACTIVATION, STIMULATE, ADHESION

View graph of relations

ID: 13908858