Publication

Antimicrobial Resistance Differs Significantly Between Hospitals: The Advantage of a Regional Analysis of Blood Culture Isolates

Berends, M. S., Meijer, B., Ott, A., Roelofs, Y., Arends, J., Hendrix, R., Glasner, C. & Friedrich, A., 2018, (Unpublished).

Research output: Contribution to conferencePosterAcademic

APA

Berends, M. S., Meijer, B., Ott, A., Roelofs, Y., Arends, J., Hendrix, R., Glasner, C., & Friedrich, A. (2018). Antimicrobial Resistance Differs Significantly Between Hospitals: The Advantage of a Regional Analysis of Blood Culture Isolates. Poster session presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, Madrid, Spain.

Author

Berends, Matthijs S. ; Meijer, Bart ; Ott, Alewijn ; Roelofs, Yvonne ; Arends, Jan ; Hendrix, Ron ; Glasner, Corinna ; Friedrich, Alexander. / Antimicrobial Resistance Differs Significantly Between Hospitals : The Advantage of a Regional Analysis of Blood Culture Isolates. Poster session presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, Madrid, Spain.

Harvard

Berends, MS, Meijer, B, Ott, A, Roelofs, Y, Arends, J, Hendrix, R, Glasner, C & Friedrich, A 2018, 'Antimicrobial Resistance Differs Significantly Between Hospitals: The Advantage of a Regional Analysis of Blood Culture Isolates', European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, Madrid, Spain, 21/04/2018 - 24/04/2018.

Standard

Antimicrobial Resistance Differs Significantly Between Hospitals : The Advantage of a Regional Analysis of Blood Culture Isolates. / Berends, Matthijs S.; Meijer, Bart; Ott, Alewijn; Roelofs, Yvonne; Arends, Jan; Hendrix, Ron; Glasner, Corinna; Friedrich, Alexander.

2018. Poster session presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, Madrid, Spain.

Research output: Contribution to conferencePosterAcademic

Vancouver

Berends MS, Meijer B, Ott A, Roelofs Y, Arends J, Hendrix R et al. Antimicrobial Resistance Differs Significantly Between Hospitals: The Advantage of a Regional Analysis of Blood Culture Isolates. 2018. Poster session presented at European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, Madrid, Spain.


BibTeX

@conference{d68523a4da474259a20d7eb585647138,
title = "Antimicrobial Resistance Differs Significantly Between Hospitals: The Advantage of a Regional Analysis of Blood Culture Isolates",
abstract = "Background: Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection. In case of a suspected case of sepsis empirical antimicrobial treatment is needed. The choice of empiric treatment is primarily an “informed guess” based on national guidelines, but also on knowledge of local and regional resistance of typically isolated microorganisms.Materials/methods: In this study, bug/drug combinations were analysed of all bacterial blood culture isolates from patients of all 14 secondary and tertiary care hospitals in the Northern Netherlands detected in the last 15 years (between 2002 to 2016). Only first isolates were selected and included by using a novel selection algorithm, based on the M39-A4 guideline of CLSI, taking into account isolate-specific resistance of key antibiotics which were chosen based on the genus and Gram stain. Subsequently, we compared the resistance of blood culture isolates between hospitals using a full-region approach.Results: Using the novel method, nearly 10% more bacterial strains were included compared to the CLSI guideline, resulting in a total of about 123,000 instead of 105,000 isolates. We show significant differences in antimicrobial resistance between hospitals, even when comparing the resistance of the same microbial species. Importantly, prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) has increased from 0.3% in 2002 to 1.4% in 2016 and Quinolone and Aminoglycoside Resistant Enterobacteriaceae (QARE) from 0.2% in 2002 to 2.4% in 2016. Nevertheless, their prevalence remains lower compared to neighbouring countries. Conclusions: Empiric therapy for patients with septicaemia might be improved in single hospitals, by analysing the regional inter-institutional epidemiology of bacteriaemic isolates comprising the correspondent resistance. It has been shown that there are major local epidemiological differences in microbial resistance, but a regional homogeneity in microbial prevalence. This allows for a more specific therapy of first choice using regional or even local hospital protocols, rather than using general national guidelines. We recommend to analyse bacterial surveillance and prevalence of resistance in a full-area approach instead of single hospitals or the national level.",
author = "Berends, {Matthijs S.} and Bart Meijer and Alewijn Ott and Yvonne Roelofs and Jan Arends and Ron Hendrix and Corinna Glasner and Alexander Friedrich",
year = "2018",
language = "English",
note = "European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018, ECCMID ; Conference date: 21-04-2018 Through 24-04-2018",
url = "http://www.eccmid.org",

}

RIS

TY - CONF

T1 - Antimicrobial Resistance Differs Significantly Between Hospitals

T2 - European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2018

AU - Berends, Matthijs S.

AU - Meijer, Bart

AU - Ott, Alewijn

AU - Roelofs, Yvonne

AU - Arends, Jan

AU - Hendrix, Ron

AU - Glasner, Corinna

AU - Friedrich, Alexander

PY - 2018

Y1 - 2018

N2 - Background: Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection. In case of a suspected case of sepsis empirical antimicrobial treatment is needed. The choice of empiric treatment is primarily an “informed guess” based on national guidelines, but also on knowledge of local and regional resistance of typically isolated microorganisms.Materials/methods: In this study, bug/drug combinations were analysed of all bacterial blood culture isolates from patients of all 14 secondary and tertiary care hospitals in the Northern Netherlands detected in the last 15 years (between 2002 to 2016). Only first isolates were selected and included by using a novel selection algorithm, based on the M39-A4 guideline of CLSI, taking into account isolate-specific resistance of key antibiotics which were chosen based on the genus and Gram stain. Subsequently, we compared the resistance of blood culture isolates between hospitals using a full-region approach.Results: Using the novel method, nearly 10% more bacterial strains were included compared to the CLSI guideline, resulting in a total of about 123,000 instead of 105,000 isolates. We show significant differences in antimicrobial resistance between hospitals, even when comparing the resistance of the same microbial species. Importantly, prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) has increased from 0.3% in 2002 to 1.4% in 2016 and Quinolone and Aminoglycoside Resistant Enterobacteriaceae (QARE) from 0.2% in 2002 to 2.4% in 2016. Nevertheless, their prevalence remains lower compared to neighbouring countries. Conclusions: Empiric therapy for patients with septicaemia might be improved in single hospitals, by analysing the regional inter-institutional epidemiology of bacteriaemic isolates comprising the correspondent resistance. It has been shown that there are major local epidemiological differences in microbial resistance, but a regional homogeneity in microbial prevalence. This allows for a more specific therapy of first choice using regional or even local hospital protocols, rather than using general national guidelines. We recommend to analyse bacterial surveillance and prevalence of resistance in a full-area approach instead of single hospitals or the national level.

AB - Background: Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection. In case of a suspected case of sepsis empirical antimicrobial treatment is needed. The choice of empiric treatment is primarily an “informed guess” based on national guidelines, but also on knowledge of local and regional resistance of typically isolated microorganisms.Materials/methods: In this study, bug/drug combinations were analysed of all bacterial blood culture isolates from patients of all 14 secondary and tertiary care hospitals in the Northern Netherlands detected in the last 15 years (between 2002 to 2016). Only first isolates were selected and included by using a novel selection algorithm, based on the M39-A4 guideline of CLSI, taking into account isolate-specific resistance of key antibiotics which were chosen based on the genus and Gram stain. Subsequently, we compared the resistance of blood culture isolates between hospitals using a full-region approach.Results: Using the novel method, nearly 10% more bacterial strains were included compared to the CLSI guideline, resulting in a total of about 123,000 instead of 105,000 isolates. We show significant differences in antimicrobial resistance between hospitals, even when comparing the resistance of the same microbial species. Importantly, prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) has increased from 0.3% in 2002 to 1.4% in 2016 and Quinolone and Aminoglycoside Resistant Enterobacteriaceae (QARE) from 0.2% in 2002 to 2.4% in 2016. Nevertheless, their prevalence remains lower compared to neighbouring countries. Conclusions: Empiric therapy for patients with septicaemia might be improved in single hospitals, by analysing the regional inter-institutional epidemiology of bacteriaemic isolates comprising the correspondent resistance. It has been shown that there are major local epidemiological differences in microbial resistance, but a regional homogeneity in microbial prevalence. This allows for a more specific therapy of first choice using regional or even local hospital protocols, rather than using general national guidelines. We recommend to analyse bacterial surveillance and prevalence of resistance in a full-area approach instead of single hospitals or the national level.

M3 - Poster

Y2 - 21 April 2018 through 24 April 2018

ER -

ID: 61151598