Publication

Anti-HIV drug development--an overview

Pereira, C. F. & Paridaen, J. T. M. L., 2004, In : Current Pharmaceutical Design. 10, 32, p. 4005-4037 33 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Highly active antiretroviral therapy (HAART) has markedly decreased mortality and morbidity in the developed world. HAART consists of a combination of three or more of the following classes of antiretroviral (ARV) drug: reverse transcriptase inhibitors, protease inhibitors and a recently approved fusion inhibitor. However, HAART cannot completely eradicate HIV from the body, results in long-term toxicity and eventually leads to the emergence of drug-resistant HIV strains. These problems prompt the search for potent new drugs that are active against drug-resistant viral strains and that can safely be combined with other ARV drugs. The aim of this review was to give an overview of new compounds in preclinical or early clinical development that interact with various steps in the HIV life cycle: virus-cell attachment; gp120-CD4 binding; gp120-coreceptor binding; viral fusion; viral assembly and disassembly; reverse transcription; nuclear import of the pre-integration complex; proviral integration; viral transcription; processing of viral transcripts and nuclear export; assembly of new virions; cellular factors involved in HIV replication.

Original languageEnglish
Pages (from-to)4005-4037
Number of pages33
JournalCurrent Pharmaceutical Design
Volume10
Issue number32
Publication statusPublished - 2004
Externally publishedYes

    Keywords

  • Animals, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Cell Line, Clinical Trials as Topic, Drug Design, Drug Evaluation, Preclinical, HIV Infections, HIV-1, Humans, Molecular Structure, Virus Replication, Journal Article, Review

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