Antifungal PK/PD in the critically Ill

Brüggemann, R. J. M., de Lange, D. W. & Jan-Willem, C. A., 18-Sep-2017, Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. Springer Singapore, p. 213-238 26 p.

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  • Antifungal PK/PD in the Critically Ill

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Invasive fungal disease (IFD) can be life-threatening. In the past two decades, the incidence of these infections has increased significantly, largely because of the increasing number of patients at risk [1]. Although IFD can affect people with an intact immune systems as well, the vast majority of these infections occur as opportunistic infections in the immunocompromised host. IFD can be caused by both yeasts and filamentous molds. Yeasts are a type of fungi that consist of solitary cells that reproduce by budding, whereas molds occur in the form of hyphae: long, tubular branches with multiple, genetically identical nuclei which grow by apical extension. The most common forms of IFD in the immunocompromised host include invasive candidiasis (yeast) and invasive aspergillosis (mold).
Original languageEnglish
Title of host publicationAntibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
PublisherSpringer Singapore
Number of pages26
ISBN (Electronic)978-981-10-5336-8
ISBN (Print)978-981-10-5335-1
Publication statusPublished - 18-Sep-2017

ID: 111909212