Publication

Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches

Hendriks, D., Choi, G., de Bruyn, M., Wiersma, V. R. & Bremer, E., 2017, International Review of Cell and Molecular Biology. Galluzi, L. & Vitale, I. (eds.). Elsevier, Vol. 331. p. 289-383 95 p. (International Review of Cell and Molecular Biology; vol. 331).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Since their discovery, antibodies have been viewed as ideal candidates or "magic bullets" for use in targeted therapy in the fields of cancer, autoimmunity, and chronic inflammatory disorders. A wave of antibody-dedicated research followed, which resulted in the clinical approval of a first generation of monoclonal antibodies for cancer therapy such as rituximab (1997) and cetuximab (2004), and infliximab (2002) for the treatment of autoimmune diseases. More recently, the development of antibodies that prevent checkpoint-mediated inhibition of T cell responses invigorated the field of cancer immunotherapy. Such antibodies induced unprecedented long-term remissions in patients with advanced stage malignancies, most notably melanoma and lung cancer, that do not respond to conventional therapies. In this review, we will recapitulate the development of antibody-based therapy, and detail recent advances and new functions, particularly in the field of cancer immunotherapy. With the advent of recombinant DNA engineering, a number of rationally designed molecular formats of antibodies and antibody-derived agents have become available, and we will discuss various molecular formats including antibodies with improved effector functions, bispecific antibodies, antibody-drug conjugates, antibody-cytokine fusion proteins, and T cells genetically modified with chimeric antigen receptors. With these exciting advances, new antibody-based treatment options will likely enter clinical practice and pave the way toward more successful control of malignant diseases.

Original languageEnglish
Title of host publicationInternational Review of Cell and Molecular Biology
EditorsLorenzo Galluzi, Ilio Vitale
PublisherElsevier
Pages289-383
Number of pages95
Volume331
ISBN (Print)978-0-12-812469-7
Publication statusPublished - 2017

Publication series

NameInternational Review of Cell and Molecular Biology
PublisherELSEVIER ACADEMIC PRESS INC
Volume331
ISSN (Print)1937-6448

    Keywords

  • CHIMERIC ANTIGEN RECEPTOR, APOPTOSIS-INDUCING LIGAND, ACUTE MYELOID-LEUKEMIA, NON-HODGKINS-LYMPHOMA, CHRONIC LYMPHOCYTIC-LEUKEMIA, TRAIL FUSION PROTEIN, B-CELL MALIGNANCIES, RICIN-A-CHAIN, CAR-T-CELLS, METASTATIC BREAST-CANCER

ID: 42135721