Publication
Antibody imaging as biomarker in early cancer drug development and treatment
Lamberts, L. E., 2016, [Groningen]: Rijksuniversiteit Groningen. 188 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 569 KB, PDF document
- Chapter 1
Final publisher's version, 572 KB, PDF document
- Chapter 2
Final publisher's version, 934 KB, PDF document
- Chapter 3
Final publisher's version, 4 MB, PDF document
- Publisher version chapter 3
Final publisher's version, 2.8 MB, PDF document
- Chapter 4
Final publisher's version, 920 KB, PDF document
- Publisher version chapter 4
Final publisher's version, 1.77 MB, PDF document
- Chapter 5
Final publisher's version, 2.12 MB, PDF document
- Publisher version chapter 5
Final publisher's version, 2.2 MB, PDF document
- Chapter 6
Final publisher's version, 2.47 MB, PDF document
- Chapter 7
Final publisher's version, 2.1 MB, PDF document
- Chapter 8
Final publisher's version, 1.75 MB, PDF document
- Chapter 9
Final publisher's version, 9.48 MB, PDF document
- Chapter 10
Final publisher's version, 580 KB, PDF document
- Chapter 11
Final publisher's version, 570 KB, PDF document
- Acknowledgements
Final publisher's version, 537 KB, PDF document
- Publications
Final publisher's version, 556 KB, PDF document
- Complete thesis
Final publisher's version, 19.9 MB, PDF document
- Propositions
Final publisher's version, 511 KB, PDF document
Molecular imaging with positron emission tomography (PET) and antibodies labeled with a radionuclide is a potential complementary molecular analysis technique and biomarker. This allows to noninvasively visualize whole body tumor uptake and biodistribution of (modified) therapeutic antibodies. In this thesis the feasibility of this approach for several antibodies and for different cancer types is shown.
Another potential form of molecular imaging in this setting is optical imaging with a fluorescent labeled antibody. This is of potential interest for intraoperative guidance and to provide detailed insight in drug localization in the tumor.
These findings, when further verified in larger trials, might support prediction of treatment efficacy and guide decision making in early clinical drug development next to use for tumor detection during surgery.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 23-May-2016 |
Place of Publication | [Groningen] |
Publisher | |
Publication status | Published - 2016 |
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