Antibiotic resistance plasmids cointegrated into a megaplasmid harbouring the blaOXA-427 carbapenemase gene

Desmet, S., Nepal, S., van Dijl, J. M., Van Ranst, M., Chlebowicz, M. A., Rossen, J. W., Van Houdt, J. K. J., Maes, P., Lagrou, K. & Bathoorn, E., Mar-2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, e01448-17.

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OXA-427 is a new class-D carbapenemase encountered in different species of Enterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.

Original languageEnglish
Article numbere01448-17
JournalAntimicrobial Agents and Chemotherapy
Issue number3
Early online date8-Jan-2018
Publication statusPublished - Mar-2018



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