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Angiogenic growth factors and their receptors in first-trimester human decidua of pregnancies further complicated by preeclampsia or fetal growth restriction

Plaisier, M., Streefland, E., Koolwijk, P., van Hinsbergh, V. W. M., Helmerhorst, F. M. & Erwich, J. J. H. M., Sep-2008, In : Reproductive Sciences. 15, 7, p. 720-726 7 p.

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DOI

  • M. Plaisier
  • E. Streefland
  • P. Koolwijk
  • V. W. M. van Hinsbergh
  • F. M. Helmerhorst
  • J. J. H. M. Erwich

Disturbances in decidual and placental vascular development may play a role in the pathogenesis of pregnancy complications. This study focused on the role of angiogenic factors in the first trimester in the pathogenesis of preeeclampsia (PF) and/or fetal growth restriction (FGR). First-trimester decidua was obtained during chorionic villous sampling. The expression of (the angiogenic factors was determined by reverse transcriptase polymerase chain reaction and related to the pregnancy outcome. First-trimester decidua expressed all angiogenic factors. The differential expression of angiogenic factors appeared to be more prominent in FGR than in PE. These first-trimester samples provided a unique opportunity to obtain information regarding the onset of PE and FGR. First-trimester changes in angiogenic factor expression may well occur as a compensator), mechanism. This, in turn, may unintentionally set the stage for increased angiogenesis and altered decidual/placental vascular adaptation, which may be part of the pathogenesis of PE and/or FGR.

Original languageEnglish
Pages (from-to)720-726
Number of pages7
JournalReproductive Sciences
Volume15
Issue number7
Publication statusPublished - Sep-2008

    Keywords

  • angiogenic factors, first trimester, decidua, preeclampsia, fetal growth restriction, MESSENGER RIBONUCLEIC-ACIDS, VILLOUS DEVELOPMENT ORIGINS, PLACENTAL GROWTH, FACTOR VEGF, FACTOR EXPRESSION, HYPOXIA, ANGIOPOIETIN-2, TISSUES, TIE2, PATHOGENESIS

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