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Aneuploidy in stem cells

Garcia-Martinez, J., Bakker, B., Schukken, K. M., Simon, J. E. & Foijer, F., 26-Jun-2016, In : World journal of stem cells. 8, 6, p. 216-22 7 p.

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Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells has brought this promise steps closer to reality. However, as somatic cells might have accumulated various chromosomal abnormalities, including aneuploidies throughout their lives, the resulting IPSCs might no longer carry the perfect blueprint for the tissue to be generated, or worse, become at risk of adopting a malignant fate. In this review, we discuss the contribution of aneuploidy to healthy tissues and how aneuploidy can lead to disease. Furthermore, we review the differences between how somatic cells and stem cells respond to aneuploidy.

Original languageEnglish
Pages (from-to)216-22
Number of pages7
JournalWorld journal of stem cells
Volume8
Issue number6
Publication statusPublished - 26-Jun-2016

    Keywords

  • Journal Article, Review, AGING-ASSOCIATED PHENOTYPES, COPY NUMBER VARIATION, CHROMOSOMAL INSTABILITY, EPIGENETIC INSTABILITY, HUMAN BLASTOCYSTS, DOWN-SYNDROME, HUMAN BRAIN, DISEASE, CANCER, MOUSE

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