Publication

ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?

Van Der Veen, B. S. & Heeringa, P., Jun-2009, In : APMIS. 117, p. 21-26 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Anti-neutrophil cytoplasmic autoantibodies (ANCA) with a specificity for myeloperoxidase or proteinase 3 are closely associated with small vessel vasculitides (SVV). In vitro, ANCA activate primed neutrophils to release toxic substances that destroy endothelial cells, suggesting a pathogenic role for these autoantibodies in disease development. However, to study the complex interplay between ANCA, neutrophils, and the local environment in vivo, animal models are required. Here, we will review the animal models developed for ANCA-SVV and discuss how these models have been applied to study ANCA-SVV pathogenesis. In addition, some directions for future research pertaining to unresolved issues relevant for the pathogenesis and immunogenesis of ANCA-SVV are proposed.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalAPMIS
Volume117
Publication statusPublished - Jun-2009
Event14th International Vasculitis and ANCA Workshop - , Denmark
Duration: 6-Jun-20099-Jun-2009

Event

14th International Vasculitis and ANCA Workshop

06/06/200909/06/2009

Denmark

Event: Other

    Keywords

  • ANCA, animal models, vasculitis, review, ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES, ENDOTHELIAL CELL-INTERACTIONS, INTERACTIONS IN-VIVO, SYSTEMIC VASCULITIS, ANTIMYELOPEROXIDASE ANTIBODIES, CRESCENTIC GLOMERULONEPHRITIS, MURINE HOMOLOG, MYELOPEROXIDASE, PROTEINASE-3, SPECIFICITY

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