Publication

Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation

Bischoff, R., Bronsema, K. J. & van de Merbel, N. C., 2013, In : TrAC-Trends in Analytical Chemistry. 48, p. 41-51 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Bischoff, R., Bronsema, K. J., & van de Merbel, N. C. (2013). Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation. TrAC-Trends in Analytical Chemistry, 48, 41-51. https://doi.org/10.1016/j.trac.2012.11.015

Author

Bischoff, Rainer ; Bronsema, Kees J. ; van de Merbel, Nico C. / Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation. In: TrAC-Trends in Analytical Chemistry. 2013 ; Vol. 48. pp. 41-51.

Harvard

Bischoff, R, Bronsema, KJ & van de Merbel, NC 2013, 'Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation', TrAC-Trends in Analytical Chemistry, vol. 48, pp. 41-51. https://doi.org/10.1016/j.trac.2012.11.015

Standard

Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation. / Bischoff, Rainer; Bronsema, Kees J.; van de Merbel, Nico C.

In: TrAC-Trends in Analytical Chemistry, Vol. 48, 2013, p. 41-51.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Bischoff R, Bronsema KJ, van de Merbel NC. Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation. TrAC-Trends in Analytical Chemistry. 2013;48:41-51. https://doi.org/10.1016/j.trac.2012.11.015


BibTeX

@article{beba86703e7d413bbc5c7c46f6fad180,
title = "Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation",
abstract = "Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.",
keywords = "Analytical procedure, Automation, Biological matrix, Biopharmaceuticals, Blood-derived body fluid, Clinical study, Liquid chromatography with tandem mass spectrometry (LC-MS/MS), Pharmacokinetic study, Protein, Sample preparation, TANDEM MASS-SPECTROMETRY, PERFORMANCE LIQUID-CHROMATOGRAPHY, PEPTIDE IMMUNOAFFINITY ENRICHMENT, ABSOLUTE QUANTIFICATION, MONOCLONAL-ANTIBODY, INTERNAL STANDARD, HUMAN SERUM, THERAPEUTIC PROTEINS, TRYPSIN DIGESTION, DEAMIDATION",
author = "Rainer Bischoff and Bronsema, {Kees J.} and {van de Merbel}, {Nico C.}",
year = "2013",
doi = "10.1016/j.trac.2012.11.015",
language = "English",
volume = "48",
pages = "41--51",
journal = "TrAC-Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparation

AU - Bischoff, Rainer

AU - Bronsema, Kees J.

AU - van de Merbel, Nico C.

PY - 2013

Y1 - 2013

N2 - Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.

AB - Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.

KW - Analytical procedure

KW - Automation

KW - Biological matrix

KW - Biopharmaceuticals

KW - Blood-derived body fluid

KW - Clinical study

KW - Liquid chromatography with tandem mass spectrometry (LC-MS/MS)

KW - Pharmacokinetic study

KW - Protein

KW - Sample preparation

KW - TANDEM MASS-SPECTROMETRY

KW - PERFORMANCE LIQUID-CHROMATOGRAPHY

KW - PEPTIDE IMMUNOAFFINITY ENRICHMENT

KW - ABSOLUTE QUANTIFICATION

KW - MONOCLONAL-ANTIBODY

KW - INTERNAL STANDARD

KW - HUMAN SERUM

KW - THERAPEUTIC PROTEINS

KW - TRYPSIN DIGESTION

KW - DEAMIDATION

U2 - 10.1016/j.trac.2012.11.015

DO - 10.1016/j.trac.2012.11.015

M3 - Article

VL - 48

SP - 41

EP - 51

JO - TrAC-Trends in Analytical Chemistry

JF - TrAC-Trends in Analytical Chemistry

SN - 0165-9936

ER -

ID: 5906034