Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS I. Sample preparationBischoff, R., Bronsema, K. J. & van de Merbel, N. C., 2013, In : TrAC-Trends in Analytical Chemistry. 48, p. 41-51 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
Part I of this review discusses sample-preparation aspects of quantifying biopharmaceutical proteins in complex biological matrices by LC-MS/MS with a focus on blood-derived body fluids. We conclude Part I with a short overview over options for automating the entire analytical procedure, which is indispensable for routine applications in pharmacokinetic and clinical studies. (C) 2013 Elsevier Ltd. All rights reserved.
|Number of pages||11|
|Journal||TrAC-Trends in Analytical Chemistry|
|Publication status||Published - 2013|
- Analytical procedure, Automation, Biological matrix, Biopharmaceuticals, Blood-derived body fluid, Clinical study, Liquid chromatography with tandem mass spectrometry (LC-MS/MS), Pharmacokinetic study, Protein, Sample preparation, TANDEM MASS-SPECTROMETRY, PERFORMANCE LIQUID-CHROMATOGRAPHY, PEPTIDE IMMUNOAFFINITY ENRICHMENT, ABSOLUTE QUANTIFICATION, MONOCLONAL-ANTIBODY, INTERNAL STANDARD, HUMAN SERUM, THERAPEUTIC PROTEINS, TRYPSIN DIGESTION, DEAMIDATION