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An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma

EORTC Melanoma Grp, Jun-2019, In : European Journal of Cancer. 114, p. 1-7 7 p.

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  • An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma

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DOI

  • EORTC Melanoma Grp

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohisto-chemistry. We also provide guidance on the description of the spatial localisation of melanoma deposits in a SLN. The histopathological features to be reported include the following: presence or absence of the metastasis, the intranodal location of the metastasis (subcapsular, parenchymal, combined, extensive confluent and extensive multifocal), the number of the metastatic deposits (1, 2-5, 6-10, 11-20 and > 20), the maximum dimension of the largest metastasis (indicating its site) and the presence of extracapsular extension and of naevus cells. This updated EORTC protocol is expected to clarify and simplify the existing procedures, ensuring a reasonable workload for the laboratory and for the pathologists resulting in cost saving with no loss, and possible increase, in accuracy. (C) 2019 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalEuropean Journal of Cancer
Volume114
Publication statusPublished - Jun-2019

    Keywords

  • Melanoma, Sentinel lymph node, Pathology protocol, Sectioning, Tumour burden, Metastasis topography, Immunohis-tochemistry, Nodal naevus cells, Recommendations, MALIGNANT-MELANOMA, IMMUNOHISTOCHEMICAL EVALUATION, PROGNOSTIC-SIGNIFICANCE, METASTATIC MELANOMA, CUTANEOUS MELANOMA, CLINICAL-RELEVANCE, TUMOR BURDEN, SURVIVAL, MICROMETASTASES, INVOLVEMENT

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