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An innovative small molecule for promoting neuroreparative strategies

Colabufo, N. A., Contino, M., Cantore, M., Berardi, F., Perrone, R., Tonazzi, A., Console, L., Panaro, M. A., Savolainen, H. & Luurtsema, G., 2018, In : RSC Advances. 8, 10, p. 5451-5458 8 p.

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Documents

DOI

  • Nicola Antonio Colabufo
  • Marialessandra Contino
  • Mariangela Cantore
  • Francesco Berardi
  • Roberto Perrone
  • Annamaria Tonazzi
  • Lara Console
  • Maria Antonietta Panaro
  • Heli Savolainen
  • Gert Luurtsema

In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of MC111, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by MC111, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the in vivo evaluation of MC111 as new tool in neuroreparative medicine.

Original languageEnglish
Pages (from-to)5451-5458
Number of pages8
JournalRSC Advances
Volume8
Issue number10
Publication statusPublished - 2018

    Keywords

  • EXPRESSION, CELLS, DERIVATIVES, BRAIN, MICE

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