Publication

An inflamed mood: studies on the role of inflammation in the pathophysiology and treatment outcome of major depressive disorder

Yang, C., 2019, [Groningen]: University of Groningen. 135 p.

Research output: ThesisThesis fully internal (DIV)Academic

Copy link to clipboard

Documents

  • Title and contents

    Final publisher's version, 550 KB, PDF document

  • Chapter 1

    Final publisher's version, 624 KB, PDF document

  • Chapter 2

    Final publisher's version, 1 MB, PDF document

  • Chapter 3

    Final publisher's version, 1 MB, PDF document

    Embargo ends: 05/07/2020

    Request copy

  • Chapter 4

    Final publisher's version, 794 KB, PDF document

    Embargo ends: 09/10/2020

    Request copy

  • Chapter 5

    Final publisher's version, 824 KB, PDF document

    Embargo ends: 09/10/2020

    Request copy

  • Chapter 6

    Final publisher's version, 689 KB, PDF document

  • Chapter 7

    Final publisher's version, 740 KB, PDF document

  • Nederlandse samenvatting

    Final publisher's version, 559 KB, PDF document

  • Words of thanks

    Final publisher's version, 261 KB, PDF document

  • List of publications

    Final publisher's version, 398 KB, PDF document

  • SHARE

    Final publisher's version, 448 KB, PDF document

  • Complete thesis

    Final publisher's version, 2 MB, PDF document

    Embargo ends: 09/10/2020

    Request copy

  • Propositions

    Final publisher's version, 318 KB, PDF document

DOI

The unclear etiology and diverse presentations of major depressive disorder (MDD) generate substantial obstacles for an accurate diagnosis and effective treatment. Here we aimed to explore the pathophysiology of MDD, and specifically treatment Resistant Depression (TRD), with a specific interest in the role of dysregulated inflammatory system.

In the first review study we describe that increased values of serum interleukin (IL)-6 and 1β tend to be more common in the melancholic subtype compared to the non-melancholic subtype or healthy controls, while C-reactive protein (CRP) may be a pointer for the non-melancholic subtype. The second paper covers that IL-6 and CRP/high sensitivity (hs)-CRP are promising markers for predicting treatment response in TRD.

Then two genetic association studies are presented in Han Chinese persons, which zoom into the FKBP5 and CNR1 genes, both involved in regulation of inflammatory response. We found that CNR1 gene variants, including rs806367, rs6454674 and the haplotype C-T-T-C of rs806366, rs806367, rs806368, and rs806370, are associated with an increased risk for MDD but also with antidepressant treatment resistance between cases/TRD patients/non-TRD patients and healthy controls. This was not the case for FKBP5 alleles, genotypes and haplotypes.

Lastly, an ongoing antidepressant augmentation trial with N-acetylcysteine is presented, that was designed to target TRD patients with inflammatory dysregulation. The design, with strengths and limitations are discussed, in attendance of the later results of this trial.

In conclusion, we propose that specific inflammatory markers and genetic variants could be promising pointers in diagnosing and predicting antidepressant treatment response for MDD/TRD.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date9-Oct-2019
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-1974-9
Electronic ISBNs978-94-034-1973-2
Publication statusPublished - 2019

View graph of relations

Download statistics

No data available

ID: 98153713