Publication

An in vitro study of cartilage-meniscus tribology to understand the changes caused by a meniscus implant

Majd, S. E., Rizqy, A. I., Kaper, H. J., Schmidt, T. A., Kuijer, R. & Sharma, P. K., 1-Jul-2017, In : Colloids and Surfaces B: Biointerfaces. 155, p. 294-303 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • An in vitro study of cartilage–meniscus tribology to understand the changes caused by a meniscus implant

    Final publisher's version, 2 MB, PDF document

DOI

Active lifestyles increase the risk of meniscal injury. A permanent meniscus implant of polycarbonate urethane (PCU) is a promising treatment to postpone/prevent total knee arthroplasty. Study of the changes in articular cartilage tribology in the presence of PCU is essential in developing the optimum meniscus implant. Therefore, a cartilage-meniscus reciprocating, sliding model was developed in vitro, mimicking the stance and swing phases of the gait cycle. The meniscus was further replaced with PCU and surface modified PCUs (with C18 chains, mono-functional polydimethylsiloxane groups and mono-functional polytetrafluoroethylene groups) to study the changes. The coefficient of friction (COF) was calculated, and cartilage wear was determined and quantified histologically. The cartilage-meniscus sliding resulted in low COF during both stance and swing (0.01 <COF <0.12) and low wear of cartilage (scores <1). The cartilage-PCU sliding, during stance, revealed similar low COFs. But during swing, the COFs were high (average similar to 1, maximum 1.6), indicating a breakdown in interstitial fluid pressurization lubrication and non-effective activation of the boundary lubrication. This may lead to wear of cartilage in long term. However, under the tested conditions the wear of cartilage against PCUs was not higher than its wear against meniscus, and the cartilage was occasionally damaged. The COF decreased with increasing the contact pressure (as-per a power equation) up to 1 MPa. The changes in the surface modification of PCU did not affect PCU's tribological performance. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)294-303
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Volume155
Publication statusPublished - 1-Jul-2017

    Keywords

  • Biotribology, Meniscus, Polycarbonate urethane, Hyaluronan, Proteoglycan-4, Phospholipid, SYNOVIAL-FLUID, ARTICULAR-CARTILAGE, BOUNDARY LUBRICATION, MOLECULAR-WEIGHT, MEDIAL MENISCUS, KNEE, REGENERATION, MENISCECTOMY, SCAFFOLDS, SUBSTITUTION

ID: 44213730