Publication

Altered Functional Connectivity in Resting State Networks in Tourette's Disorder

Fan, S., van den Heuvel, O. A., Cath, D. C., de Wit, S. J., Vriend, C., Veltman, D. J. & van der Werf, Y. D., 18-Sep-2018, In : Frontiers in Human Neuroscience. 12, 9 p., 363.

Research output: Contribution to journalArticleAcademicpeer-review

  • Siyan Fan
  • Odile A. van den Heuvel
  • Danielle C. Cath
  • Stella J. de Wit
  • Chris Vriend
  • Dick J. Veltman
  • Ysbrand D. van der Werf

Introduction: Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette's disorder (TD). By using resting-state functional MRI, we aimed to identify alterations in the default mode network (DMN), frontal-parietal network (FPN), sensori-motor network (SMN), and salience network (SN) in TD compared with healthy control (HC) subjects.

Method: In 23 adult TD patients and 22 HC, 3T-MRI resting-state scans were obtained. Independent component analysis was performed comparing TD and HC to investigate connectivity patterns within and between resting-state networks.

Results: TD patients showed higher involvement of the dorsal medial prefrontal cortex in the connectivity of the DMN and less involvement of the inferior parietal cortex in the connectivity of the FPN when compared to HC. Moreover, TD patients showed a stronger coupling between DMN and left FPN than HC. Finally, in TD patients, functional connectivity within DMN correlated negatively with tic severity.

Conclusion: We tentatively interpret the increased functional connectivity within DMN in TD patients as compensatory to the lower functional connectivity within left FPN. The stronger coupling between DMN and left FPN, together with the finding that higher DMN intrinsic connectivity is associated with lower tic severity would indicate that DMN is recruited to exert motor inhibition.

Original languageEnglish
Article number363
Number of pages9
JournalFrontiers in Human Neuroscience
Volume12
Publication statusPublished - 18-Sep-2018

    Keywords

  • resting-Ss, Tourette Syndrome, functional connectivity (FC), default mode network (DMN), frontal-parietal network, OBSESSIVE-COMPULSIVE DISORDER, ENHANCED COGNITIVE CONTROL, HUNTINGTONS-DISEASE, PARKINSONS-DISEASE, PARIETAL CORTEX, BASAL GANGLIA, HUMAN BRAIN, INVENTORY, ORGANIZATION, MODULATION

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