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Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

van der Schee, M. P., Hashimoto, S., Schuurman, A. C., van Driel, J. S. R., Adriaens, N., van Amelsfoort, R. M., Snoeren, T., Regenboog, M., Sprikkelman, A. B., Haarman, E. G., van Aalderen, W. M. C. & Sterk, P. J., Feb-2015, In : European Respiratory Journal. 45, 2, p. 440-448 9 p.

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  • Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze

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DOI

  • Marc P. van der Schee
  • Simone Hashimoto
  • Annemarie C. Schuurman
  • Janine S. Repelaer van Driel
  • Nora Adriaens
  • Romy M. van Amelsfoort
  • Tessa Snoeren
  • Martine Regenboog
  • Aline B. Sprikkelman
  • Eric G. Haarman
  • Wim M. C. van Aalderen
  • Peter J. Sterk

Preschool rhinovirus-induced wheeze is associated with an increased risk of asthma. In adult asthma, exhaled volatile organic compounds (VOC) are associated with inflammatory activity. We therefore hypothesised that acute preschool wheeze is accompanied by a differential profile of exhaled VOC, which is maintained after resolution of symptoms in those children with rhinovirus-induced wheeze.

We included 178 children (mean +/- SD age 22 +/- 9 months) from the EUROPA cohort comparing asymptomatic and wheezing children during respiratory symptoms and after recovery. Naso- and oropharyngeal swabs were tested for rhinovirus by quantitative PCR. Breath was collected via a spacer and analysed using an electronic nose. Between-group discrimination was assessed by constructing a 1000-fold cross-validated receiver operating characteristic curve. Analyses were stratified by rhinovirus presence/absence.

Wheezing children demonstrated a different VOC profile when compared with asymptomatic children (p

Exhaled molecular profiles differ between preschool children with and without acute respiratory wheeze. This appears to be sustained in children with rhinovirus-induced wheeze after resolution of symptoms. Therefore, exhaled VOC may qualify as candidate biomarkers for early signs of asthma.

Original languageEnglish
Pages (from-to)440-448
Number of pages9
JournalEuropean Respiratory Journal
Volume45
Issue number2
Publication statusPublished - Feb-2015
Externally publishedYes

    Keywords

  • VOLATILE ORGANIC-COMPOUNDS, 1ST 6 YEARS, NITRIC-OXIDE, PRESCHOOL WHEEZERS, CHILDHOOD ASTHMA, VIRAL-INFECTIONS, ELECTRONIC NOSE, FOLLOW-UP, BREATH, LIFE

ID: 71333368