Publication

Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers

Mackus, M., Lantman, M. V. S., Van de Loo, A. J. A. E., Kraneveld, A. D., Garssen, J., Brookhuis, K. A. & Verster, J. C., 1-Apr-2018, In : Drug and Alcohol Dependence. 185, p. 351-355 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Mackus, M., Lantman, M. V. S., Van de Loo, A. J. A. E., Kraneveld, A. D., Garssen, J., Brookhuis, K. A., & Verster, J. C. (2018). Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. Drug and Alcohol Dependence, 185, 351-355. https://doi.org/10.1016/j.drugalcdep.2017.11.040

Author

Mackus, M. ; Lantman, M. van Schrojenstein ; Van de Loo, A. J. A. E. ; Kraneveld, A. D. ; Garssen, J. ; Brookhuis, K. A. ; Verster, J. C. / Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. In: Drug and Alcohol Dependence. 2018 ; Vol. 185. pp. 351-355.

Harvard

Mackus, M, Lantman, MVS, Van de Loo, AJAE, Kraneveld, AD, Garssen, J, Brookhuis, KA & Verster, JC 2018, 'Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers', Drug and Alcohol Dependence, vol. 185, pp. 351-355. https://doi.org/10.1016/j.drugalcdep.2017.11.040

Standard

Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. / Mackus, M.; Lantman, M. van Schrojenstein; Van de Loo, A. J. A. E.; Kraneveld, A. D.; Garssen, J.; Brookhuis, K. A.; Verster, J. C.

In: Drug and Alcohol Dependence, Vol. 185, 01.04.2018, p. 351-355.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Mackus M, Lantman MVS, Van de Loo AJAE, Kraneveld AD, Garssen J, Brookhuis KA et al. Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. Drug and Alcohol Dependence. 2018 Apr 1;185:351-355. https://doi.org/10.1016/j.drugalcdep.2017.11.040


BibTeX

@article{7d92d88e6d9d4756a5abfec2e68b9dd4,
title = "Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers",
abstract = "Background: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers.Methods: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate. It was aimed to include 12 hangover resistant drinkers and 12 hangover sensitive drinkers. Participants consumed alcohol to reach a breath alcohol concentration (BrAC) of 0.05{\%}. Every 5 min BrAC was determined, until BrAC reached zero. Every 15 min, the Karolinska Sleeping Scale (KSS) was administered to assess subjective sleepiness, and subjective intoxication was measured.Results: Data of N = 23 participants with a mean age of 22.4 (+/- 1.9) years was included in the analyses. No significant difference in BrAC over time was found between the hangover resistant group and the hangover sensitive group. In line, subjective sleepiness scores and subjective intoxication ratings did not significantly differ between the groups at any point in time after alcohol consumption.Conclusion: Hangover resistant individuals and hangover sensitive drinkers did not significantly differ on BrAC, subjective sleepiness, and subjective intoxication after consuming a moderate amount of alcohol. These findings suggest that drinkers who usually experience hangovers after a heavy drinking occasion do not experience alcohol intoxication differently than hangover resistant drinkers.",
keywords = "Hangover, Alcohol, Metabolism, Breath alcohol concentration, Sleepiness, Subjective intoxication, SUBJECTIVE INTOXICATION, ALDEHYDE DEHYDROGENASE, ETHANOL-METABOLISM, ENERGY DRINK, DOUBLE-BLIND, CONSUMPTION",
author = "M. Mackus and Lantman, {M. van Schrojenstein} and {Van de Loo}, {A. J. A. E.} and Kraneveld, {A. D.} and J. Garssen and Brookhuis, {K. A.} and Verster, {J. C.}",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.drugalcdep.2017.11.040",
language = "English",
volume = "185",
pages = "351--355",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "ELSEVIER IRELAND LTD",

}

RIS

TY - JOUR

T1 - Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers

AU - Mackus, M.

AU - Lantman, M. van Schrojenstein

AU - Van de Loo, A. J. A. E.

AU - Kraneveld, A. D.

AU - Garssen, J.

AU - Brookhuis, K. A.

AU - Verster, J. C.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers.Methods: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate. It was aimed to include 12 hangover resistant drinkers and 12 hangover sensitive drinkers. Participants consumed alcohol to reach a breath alcohol concentration (BrAC) of 0.05%. Every 5 min BrAC was determined, until BrAC reached zero. Every 15 min, the Karolinska Sleeping Scale (KSS) was administered to assess subjective sleepiness, and subjective intoxication was measured.Results: Data of N = 23 participants with a mean age of 22.4 (+/- 1.9) years was included in the analyses. No significant difference in BrAC over time was found between the hangover resistant group and the hangover sensitive group. In line, subjective sleepiness scores and subjective intoxication ratings did not significantly differ between the groups at any point in time after alcohol consumption.Conclusion: Hangover resistant individuals and hangover sensitive drinkers did not significantly differ on BrAC, subjective sleepiness, and subjective intoxication after consuming a moderate amount of alcohol. These findings suggest that drinkers who usually experience hangovers after a heavy drinking occasion do not experience alcohol intoxication differently than hangover resistant drinkers.

AB - Background: Previous research demonstrated that urinary ethanol concentrations were significantly lower in hangover resistant individuals compared to drinkers who reported having a hangover. This finding suggests that the rate of ethanol metabolism is faster in drinkers who do not experience an alcohol hangover. This study aimed to directly compare alcohol metabolism after administering a low dose of ethanol to hangover sensitive drinkers and hangover resistant drinkers.Methods: Social drinkers who previously participated in hangover trials at Utrecht University were invited to participate. It was aimed to include 12 hangover resistant drinkers and 12 hangover sensitive drinkers. Participants consumed alcohol to reach a breath alcohol concentration (BrAC) of 0.05%. Every 5 min BrAC was determined, until BrAC reached zero. Every 15 min, the Karolinska Sleeping Scale (KSS) was administered to assess subjective sleepiness, and subjective intoxication was measured.Results: Data of N = 23 participants with a mean age of 22.4 (+/- 1.9) years was included in the analyses. No significant difference in BrAC over time was found between the hangover resistant group and the hangover sensitive group. In line, subjective sleepiness scores and subjective intoxication ratings did not significantly differ between the groups at any point in time after alcohol consumption.Conclusion: Hangover resistant individuals and hangover sensitive drinkers did not significantly differ on BrAC, subjective sleepiness, and subjective intoxication after consuming a moderate amount of alcohol. These findings suggest that drinkers who usually experience hangovers after a heavy drinking occasion do not experience alcohol intoxication differently than hangover resistant drinkers.

KW - Hangover

KW - Alcohol

KW - Metabolism

KW - Breath alcohol concentration

KW - Sleepiness

KW - Subjective intoxication

KW - SUBJECTIVE INTOXICATION

KW - ALDEHYDE DEHYDROGENASE

KW - ETHANOL-METABOLISM

KW - ENERGY DRINK

KW - DOUBLE-BLIND

KW - CONSUMPTION

U2 - 10.1016/j.drugalcdep.2017.11.040

DO - 10.1016/j.drugalcdep.2017.11.040

M3 - Article

VL - 185

SP - 351

EP - 355

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -

ID: 78921518