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Alcohol Interactions with Lipid Bilayers

Kondela, T., Gallová, J., Hauß, T., Barnoud, J., Marrink, S-J. & Kučerka, N., 28-Nov-2017, In : Molecules. 22, 12, 15 p., 2078.

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DOI

  • Tomáš Kondela
  • Jana Gallová
  • Thomas Hauß
  • Jonathan Barnoud
  • Siewert-J Marrink
  • Norbert Kučerka

We investigate the structural changes to lipid membrane that ensue from the addition of aliphatic alcohols with various alkyl tail lengths. Small angle neutron diffraction from flat lipid bilayers that are hydrated through water vapor has been employed to eliminate possible artefacts of the membrane curvature and the alcohol's membrane-water partitioning. We have observed clear changes to membrane structure in both transversal and lateral directions. Most importantly, our results suggest the alteration of the membrane-water interface. The water encroachment has shifted in the way that alcohol loaded bilayers absorbed more water molecules when compared to the neat lipid bilayers. The experimental results have been corroborated by molecular dynamics simulations to reveal further details. Namely, the order parameter profiles have been fruitful in correlating the mechanical model of structural changes to the effect of anesthesia.

Original languageEnglish
Article number2078
Number of pages15
JournalMolecules
Volume22
Issue number12
Publication statusPublished - 28-Nov-2017

    Keywords

  • Journal Article, general anesthetics, ALCOHOLS, lipid bilayers, small-angle neutron diffraction, molecular dynamics simulations, bilayer thickness, area per lipid, order parameter, lateral pressure, THERMODYNAMICS

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