Publication

Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children

van den Belt, S. M., 2018, [Groningen]: Rijksuniversiteit Groningen. 125 p.

Research output: ThesisThesis fully internal (DIV)

APA

van den Belt, S. M. (2018). Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. Rijksuniversiteit Groningen.

Author

van den Belt, Sophie Mariëlle. / Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. [Groningen] : Rijksuniversiteit Groningen, 2018. 125 p.

Harvard

van den Belt, SM 2018, 'Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children', Doctor of Philosophy, University of Groningen, [Groningen].

Standard

Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. / van den Belt, Sophie Mariëlle.

[Groningen] : Rijksuniversiteit Groningen, 2018. 125 p.

Research output: ThesisThesis fully internal (DIV)

Vancouver

van den Belt SM. Albuminuria: more than a renal risk marker? About the prevalence, measurement, and treatment of albuminuria in children. [Groningen]: Rijksuniversiteit Groningen, 2018. 125 p.


BibTeX

@phdthesis{55410c143ef84709ba34f11fa9d911c1,
title = "Albuminuria: more than a renal risk marker?: About the prevalence, measurement, and treatment of albuminuria in children",
abstract = "Albuminuria is considered an important therapeutic target in adult renal and cardiovascular disease. The presence of higher levels of urinary albumin in babies and children, appears to make albuminuria an inborn characteristic. The availability of a treatment target which is already present at birth is important, as it could facilitate a shift from intervention to prevention of disease. This thesis investigates the measurement, prevalence and treatment of albuminuria in children, in order to increase the knowledge on this subject, and enable future research in this area. The best way to collect urine in young children appeared to be the PeeSpot, which was the most reliable and practical instrument in the assessment of albuminuria. Additionally, the optimal strategy for measuring and monitoring albuminuria in toddlers was the collection of three consecutive first morning voids, repeated over time. Use of albumin:creatinine ratio caused more variability and relative high values compared to adults. The natural distribution of albuminuria levels was not different between toddlers and adults, and the prevalence of microalbuminuria was strikingly similar between the toddler and adult cohort. This implied that abnormal values of albumin in the urine occurred already early in life, and that high albuminuria levels was therefore not always the consequence of diseases occurring later in life. Treatment of albuminuria in children with chronic kidney disease showed that lowering of proteinuria with standardized ACE inhibition was protective for renal disease progression. Moreover, discontinuation of RAAS inhibition appeared to accelerate renal function decline.",
author = "{van den Belt}, {Sophie Mari{\"e}lle}",
year = "2018",
language = "English",
isbn = "978-94-034-0646-6",
publisher = "Rijksuniversiteit Groningen",
school = "University of Groningen",

}

RIS

TY - THES

T1 - Albuminuria: more than a renal risk marker?

T2 - About the prevalence, measurement, and treatment of albuminuria in children

AU - van den Belt, Sophie Mariëlle

PY - 2018

Y1 - 2018

N2 - Albuminuria is considered an important therapeutic target in adult renal and cardiovascular disease. The presence of higher levels of urinary albumin in babies and children, appears to make albuminuria an inborn characteristic. The availability of a treatment target which is already present at birth is important, as it could facilitate a shift from intervention to prevention of disease. This thesis investigates the measurement, prevalence and treatment of albuminuria in children, in order to increase the knowledge on this subject, and enable future research in this area. The best way to collect urine in young children appeared to be the PeeSpot, which was the most reliable and practical instrument in the assessment of albuminuria. Additionally, the optimal strategy for measuring and monitoring albuminuria in toddlers was the collection of three consecutive first morning voids, repeated over time. Use of albumin:creatinine ratio caused more variability and relative high values compared to adults. The natural distribution of albuminuria levels was not different between toddlers and adults, and the prevalence of microalbuminuria was strikingly similar between the toddler and adult cohort. This implied that abnormal values of albumin in the urine occurred already early in life, and that high albuminuria levels was therefore not always the consequence of diseases occurring later in life. Treatment of albuminuria in children with chronic kidney disease showed that lowering of proteinuria with standardized ACE inhibition was protective for renal disease progression. Moreover, discontinuation of RAAS inhibition appeared to accelerate renal function decline.

AB - Albuminuria is considered an important therapeutic target in adult renal and cardiovascular disease. The presence of higher levels of urinary albumin in babies and children, appears to make albuminuria an inborn characteristic. The availability of a treatment target which is already present at birth is important, as it could facilitate a shift from intervention to prevention of disease. This thesis investigates the measurement, prevalence and treatment of albuminuria in children, in order to increase the knowledge on this subject, and enable future research in this area. The best way to collect urine in young children appeared to be the PeeSpot, which was the most reliable and practical instrument in the assessment of albuminuria. Additionally, the optimal strategy for measuring and monitoring albuminuria in toddlers was the collection of three consecutive first morning voids, repeated over time. Use of albumin:creatinine ratio caused more variability and relative high values compared to adults. The natural distribution of albuminuria levels was not different between toddlers and adults, and the prevalence of microalbuminuria was strikingly similar between the toddler and adult cohort. This implied that abnormal values of albumin in the urine occurred already early in life, and that high albuminuria levels was therefore not always the consequence of diseases occurring later in life. Treatment of albuminuria in children with chronic kidney disease showed that lowering of proteinuria with standardized ACE inhibition was protective for renal disease progression. Moreover, discontinuation of RAAS inhibition appeared to accelerate renal function decline.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-0646-6

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

ID: 58536648