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AGONIST EFFECTS AT PUTATIVE CENTRAL 5-HT(4)RECEPTORS IN RAT HIPPOCAMPUS BY R(+)-ZACOPRIDE AND S(-)-ZACOPRIDE - NO EVIDENCE FOR STEREOSELECTIVITY

BODDEKE, HWGM. & KALKMAN, HO., 6-Jan-1992, In : Neuroscience Letters. 134, 2, p. 261-263 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

The EEG of halothane anaesthetized rats was recorded from an electrode implanted into the hippocampus. In the present study the effect of R(+)- and S()-zacopride, administered intra-cerebroventricularly, on different frequency bands of the EEG was investigated. Both enantiomers induced similar dose-dependent (5-20-mu-g) increases in all frequency bands. The effects of R(+)- and S()-zacopride were inhibited by pretreatment with a high dose of ICS 205-930 (1-mu-g i.c.v.), which suggests the involvement of 5-HT4 receptors. The lack of stereo-selectivity of the zacopride enantiomers is in contrast to observations made in in vitro studies.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalNeuroscience Letters
Volume134
Issue number2
Publication statusPublished - 6-Jan-1992

    Keywords

  • ZACOPRIDE ENANTIOMER, EEG ACTIVITY, 5-HYDROXYTRYPTAMINE(4)RECEPTOR, ADENYLATE-CYCLASE, ZACOPRIDE, RECEPTORS, 5-HT3, PROFILE, BINDING, SITES, DRUGS

ID: 14149328