Agonist effects at putative central 5-HT4receptors in rat hippocampus by R(+)- and S(-)-zacopride; no evidence for stereo-selectivity

Boddeke, H. W. G. M. & Kalkman, H. O., 12-Nov-1992, In : Neuroscience Letters. 134, 2, p. 261-263 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

The EEG of halothane anaesthetized rats was recorded from an electrode implanted into the hippocampus. In the present study the effect of R(+)- and S(-)-zacopride, administered intra-cerebroventricularly, on different frequency bands of the EEG was investigated. Both enantiomers induced similar dose-dependent (5-20 μg) increases in all frequency bands. The effects of R(+)- and S(-)-zacopride were inhibited by pretreatment with a high dose of ICS 205-930 (1 μg i.c.v.), which suggests the involvement of 5-HT4receptors. The lack of stereo-selectivity of the zacopride enantiomers is in contrast to observations made in in vitro studies.
Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 12-Nov-1992


  • 5-hydroxytryptamine4receptor, EEG activity, zacopride enantiomer, serotonin antagonist, serotonin receptor, tropisetron, zacopride, animal experiment, article, electroencephalography, enantiomer, hippocampus, intracerebroventricular drug administration, male, nonhuman, priority journal, rat

ID: 14296992