Publication

Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Werhahn, J. E., Mohl, S., Willinger, D., Smigielski, L., Roth, A., Hofstetter, C., Stampfli, P., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U. M. E., Lythgoe, D. J., Sethi, A., Craig, M. C., Mastroianni, M., Sagar-Ouriaghli, I., Santosh, P. J., Rosa, M., Bargallo, N., Castro-Fornieles, J., Arango, C., Penzo, M. J., Zwiers, M. P., Franke, B., Buitelaar, J. K., Walitza, S. & Brandeis, D., 13-Aug-2020, In : European Child & Adolescent Psychiatry. 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Werhahn, J. E., Mohl, S., Willinger, D., Smigielski, L., Roth, A., Hofstetter, C., Stampfli, P., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Deters, R. K., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U. M. E., ... Brandeis, D. (2020). Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior. European Child & Adolescent Psychiatry. https://doi.org/10.1007/s00787-020-01601-9

Author

Werhahn, Julia E. ; Mohl, Susanna ; Willinger, David ; Smigielski, Lukasz ; Roth, Alexander ; Hofstetter, Christoph ; Stampfli, Philipp ; Naaijen, Jilly ; Mulder, Leandra M. ; Glennon, Jeffrey C. ; Hoekstra, Pieter J. ; Dietrich, Andrea ; Deters, Renee Kleine ; Aggensteiner, Pascal M. ; Holz, Nathalie E. ; Baumeister, Sarah ; Banaschewski, Tobias ; Saam, Melanie C. ; Schulze, Ulrike M. E. ; Lythgoe, David J. ; Sethi, Arjun ; Craig, Michael C. ; Mastroianni, Mathilde ; Sagar-Ouriaghli, Ilyas ; Santosh, Paramala J. ; Rosa, Mireia ; Bargallo, Nuria ; Castro-Fornieles, Josefina ; Arango, Celso ; Penzo, Maria J. ; Zwiers, Marcel P. ; Franke, Barbara ; Buitelaar, Jan K. ; Walitza, Susanne ; Brandeis, Daniel. / Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior. In: European Child & Adolescent Psychiatry. 2020.

Harvard

Werhahn, JE, Mohl, S, Willinger, D, Smigielski, L, Roth, A, Hofstetter, C, Stampfli, P, Naaijen, J, Mulder, LM, Glennon, JC, Hoekstra, PJ, Dietrich, A, Deters, RK, Aggensteiner, PM, Holz, NE, Baumeister, S, Banaschewski, T, Saam, MC, Schulze, UME, Lythgoe, DJ, Sethi, A, Craig, MC, Mastroianni, M, Sagar-Ouriaghli, I, Santosh, PJ, Rosa, M, Bargallo, N, Castro-Fornieles, J, Arango, C, Penzo, MJ, Zwiers, MP, Franke, B, Buitelaar, JK, Walitza, S & Brandeis, D 2020, 'Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior', European Child & Adolescent Psychiatry. https://doi.org/10.1007/s00787-020-01601-9

Standard

Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior. / Werhahn, Julia E.; Mohl, Susanna; Willinger, David; Smigielski, Lukasz; Roth, Alexander; Hofstetter, Christoph; Stampfli, Philipp; Naaijen, Jilly; Mulder, Leandra M.; Glennon, Jeffrey C.; Hoekstra, Pieter J.; Dietrich, Andrea; Deters, Renee Kleine; Aggensteiner, Pascal M.; Holz, Nathalie E.; Baumeister, Sarah; Banaschewski, Tobias; Saam, Melanie C.; Schulze, Ulrike M. E.; Lythgoe, David J.; Sethi, Arjun; Craig, Michael C.; Mastroianni, Mathilde; Sagar-Ouriaghli, Ilyas; Santosh, Paramala J.; Rosa, Mireia; Bargallo, Nuria; Castro-Fornieles, Josefina; Arango, Celso; Penzo, Maria J.; Zwiers, Marcel P.; Franke, Barbara; Buitelaar, Jan K.; Walitza, Susanne; Brandeis, Daniel.

In: European Child & Adolescent Psychiatry, 13.08.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Werhahn JE, Mohl S, Willinger D, Smigielski L, Roth A, Hofstetter C et al. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior. European Child & Adolescent Psychiatry. 2020 Aug 13. https://doi.org/10.1007/s00787-020-01601-9


BibTeX

@article{786c1cba06784aa9862390da6d2c81d6,
title = "Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior",
abstract = "There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02-18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala-precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control.",
keywords = "Reactive aggression, Proactive aggression, Callous-unemotional traits, Default mode network, Amygdala, Functional connectivity, CALLOUS-UNEMOTIONAL TRAITS, DEFAULT MODE NETWORK, PROACTIVE AGGRESSION, PSYCHOPATHIC TRAITS, CONDUCT DISORDER, AMYGDALA, INVENTORY, NEUROBIOLOGY, OFFENDERS",
author = "Werhahn, {Julia E.} and Susanna Mohl and David Willinger and Lukasz Smigielski and Alexander Roth and Christoph Hofstetter and Philipp Stampfli and Jilly Naaijen and Mulder, {Leandra M.} and Glennon, {Jeffrey C.} and Hoekstra, {Pieter J.} and Andrea Dietrich and Deters, {Renee Kleine} and Aggensteiner, {Pascal M.} and Holz, {Nathalie E.} and Sarah Baumeister and Tobias Banaschewski and Saam, {Melanie C.} and Schulze, {Ulrike M. E.} and Lythgoe, {David J.} and Arjun Sethi and Craig, {Michael C.} and Mathilde Mastroianni and Ilyas Sagar-Ouriaghli and Santosh, {Paramala J.} and Mireia Rosa and Nuria Bargallo and Josefina Castro-Fornieles and Celso Arango and Penzo, {Maria J.} and Zwiers, {Marcel P.} and Barbara Franke and Buitelaar, {Jan K.} and Susanne Walitza and Daniel Brandeis",
year = "2020",
month = aug,
day = "13",
doi = "10.1007/s00787-020-01601-9",
language = "English",
journal = "European Child & Adolescent Psychiatry",
issn = "1018-8827",
publisher = "SPRINGER",

}

RIS

TY - JOUR

T1 - Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

AU - Werhahn, Julia E.

AU - Mohl, Susanna

AU - Willinger, David

AU - Smigielski, Lukasz

AU - Roth, Alexander

AU - Hofstetter, Christoph

AU - Stampfli, Philipp

AU - Naaijen, Jilly

AU - Mulder, Leandra M.

AU - Glennon, Jeffrey C.

AU - Hoekstra, Pieter J.

AU - Dietrich, Andrea

AU - Deters, Renee Kleine

AU - Aggensteiner, Pascal M.

AU - Holz, Nathalie E.

AU - Baumeister, Sarah

AU - Banaschewski, Tobias

AU - Saam, Melanie C.

AU - Schulze, Ulrike M. E.

AU - Lythgoe, David J.

AU - Sethi, Arjun

AU - Craig, Michael C.

AU - Mastroianni, Mathilde

AU - Sagar-Ouriaghli, Ilyas

AU - Santosh, Paramala J.

AU - Rosa, Mireia

AU - Bargallo, Nuria

AU - Castro-Fornieles, Josefina

AU - Arango, Celso

AU - Penzo, Maria J.

AU - Zwiers, Marcel P.

AU - Franke, Barbara

AU - Buitelaar, Jan K.

AU - Walitza, Susanne

AU - Brandeis, Daniel

PY - 2020/8/13

Y1 - 2020/8/13

N2 - There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02-18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala-precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control.

AB - There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02-18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala-precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control.

KW - Reactive aggression

KW - Proactive aggression

KW - Callous-unemotional traits

KW - Default mode network

KW - Amygdala

KW - Functional connectivity

KW - CALLOUS-UNEMOTIONAL TRAITS

KW - DEFAULT MODE NETWORK

KW - PROACTIVE AGGRESSION

KW - PSYCHOPATHIC TRAITS

KW - CONDUCT DISORDER

KW - AMYGDALA

KW - INVENTORY

KW - NEUROBIOLOGY

KW - OFFENDERS

U2 - 10.1007/s00787-020-01601-9

DO - 10.1007/s00787-020-01601-9

M3 - Article

JO - European Child & Adolescent Psychiatry

JF - European Child & Adolescent Psychiatry

SN - 1018-8827

ER -

ID: 132903411