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Age-related myelin degradation burdens the clearance function of microglia during aging

Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J. & Simons, M., 13-Jun-2016, In : Nature neuroscience. 19, 8, p. 995-998 4 p.

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  • Age-related myelin degradation burdens the clearance function of microglia

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DOI

  • Shima Safaiyan
  • Nirmal Kannaiyan
  • Nicolas Snaidero
  • Simone Brioschi
  • Knut Biber
  • Simon Yona
  • Aimee L. Edinger
  • Steffen Jung
  • Moritz J. Rossner
  • Mikael Simons

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

Original languageEnglish
Pages (from-to)995-998
Number of pages4
JournalNature neuroscience
Volume19
Issue number8
Publication statusPublished - 13-Jun-2016

    Keywords

  • NERVOUS-SYSTEM, CNS, BRAIN, CELLS, MICE, DYNAMICS, DEMYELINATION, DELETION, TISSUE

ID: 40507100