Publication

Age-of-onset information helps identify 76 genetic variants associated with allergic disease

23andMe Res Team, Collaborators SHARE Study, Ferreira, M. A. R., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., Lu, Y., Grosche, S., Rueschendorf, F., Granell, R., Brumpton, B. M., Fritsche, L. G., Bhatta, L., Gabrielsen, M. E., Nielsen, J. B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O. L., Loset, M., Abecasis, G. R., Willer, C. J., Emami, N. C., Cavazos, T. B., Witte, J. S., Szwajda, A., Hinds, D. A., Huebner, N., Weidinger, S., Magnusson, P. K. E., Jorgenson, E., Karlsson, R., Paternoster, L., Boomsma, D., Almqvist, C., Lee, Y-A. & Koppelman, G. H., Jun-2020, In : PLoS genetics. 16, 6, 30 p., e1008725.

Research output: Contribution to journalArticleAcademicpeer-review

  • 23andMe Res Team
  • Collaborators SHARE Study
  • Manuel A. R. Ferreira
  • Judith M. Vonk
  • Hansjoerg Baurecht
  • Ingo Marenholz
  • Chao Tian
  • Joshua D. Hoffman
  • Quinta Helmer
  • Annika Tillander
  • Vilhelmina Ullemar
  • Yi Lu
  • Sarah Grosche
  • Franz Rueschendorf
  • Raquel Granell
  • Ben M. Brumpton
  • Lars G. Fritsche
  • Laxmi Bhatta
  • Maiken E. Gabrielsen
  • Jonas B. Nielsen
  • Wei Zhou
  • Kristian Hveem
  • Arnulf Langhammer
  • Oddgeir L. Holmen
  • Mari Loset
  • Goncalo R. Abecasis
  • Cristen J. Willer
  • Nima C. Emami
  • Taylor B. Cavazos
  • John S. Witte
  • Agnieszka Szwajda
  • David A. Hinds
  • Norbert Huebner
  • Stephan Weidinger
  • Patrik K. E. Magnusson
  • Eric Jorgenson
  • Robert Karlsson
  • Lavinia Paternoster
  • Dorret Boomsma
  • Catarina Almqvist
  • Young-Ae Lee
  • Gerard H. Koppelman

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. For each individual, we identified the earliest age at which asthma, hay fever and/or eczema was first diagnosed and performed a genome-wide association study (GWAS) of this combined age-of-onset phenotype. We identified 50 variants with a significant independent association (P

Author summary So far, genetic studies of allergic disease have investigated the presence of the disease rather than the age at which the first allergic symptoms develop. We aimed to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema by examining 117,130 genotyped individuals of European ancestry from the UK Biobank study. We identified 50 variants with a significant independent association (P

Original languageEnglish
Article numbere1008725
Number of pages30
JournalPLoS genetics
Volume16
Issue number6
Publication statusPublished - Jun-2020

    Keywords

  • GENOME-WIDE ASSOCIATION, ATOPIC-DERMATITIS, SUSCEPTIBILITY LOCI, T-CELLS, CD200 RECEPTOR, II RECEPTOR, RISK LOCI, HAY-FEVER, PKC-THETA, ASTHMA

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