Publication

After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly

Darvishian, M., Gefenaite, G., Turner, R. M., Pechlivanoglou, P., Van der Hoek, W., Van den Heuvel, E. R. & Hak, E., Jul-2014, In : Journal of Clinical Epidemiology. 67, 7, p. 734-744 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Darvishian, M., Gefenaite, G., Turner, R. M., Pechlivanoglou, P., Van der Hoek, W., Van den Heuvel, E. R., & Hak, E. (2014). After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. Journal of Clinical Epidemiology, 67(7), 734-744. https://doi.org/10.1016/j.jclinepi.2014.02.009

Author

Darvishian, Maryam ; Gefenaite, Giedre ; Turner, Rebecca M ; Pechlivanoglou, Petros ; Van der Hoek, Wim ; Van den Heuvel, Edwin R ; Hak, Eelko. / After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. In: Journal of Clinical Epidemiology. 2014 ; Vol. 67, No. 7. pp. 734-744.

Harvard

Darvishian, M, Gefenaite, G, Turner, RM, Pechlivanoglou, P, Van der Hoek, W, Van den Heuvel, ER & Hak, E 2014, 'After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly', Journal of Clinical Epidemiology, vol. 67, no. 7, pp. 734-744. https://doi.org/10.1016/j.jclinepi.2014.02.009

Standard

After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. / Darvishian, Maryam; Gefenaite, Giedre; Turner, Rebecca M; Pechlivanoglou, Petros; Van der Hoek, Wim; Van den Heuvel, Edwin R; Hak, Eelko.

In: Journal of Clinical Epidemiology, Vol. 67, No. 7, 07.2014, p. 734-744.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Darvishian M, Gefenaite G, Turner RM, Pechlivanoglou P, Van der Hoek W, Van den Heuvel ER et al. After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly. Journal of Clinical Epidemiology. 2014 Jul;67(7):734-744. https://doi.org/10.1016/j.jclinepi.2014.02.009


BibTeX

@article{712afac42af0441aa6a214a965ddffd2,
title = "After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly",
abstract = "OBJECTIVE: To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older.STUDY DESIGN AND SETTING: Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hospitalization from influenza and/or pneumonia, and all-cause mortality were study outcomes. Potential biases were identified using bias checklists. The magnitude and uncertainty of biases were assessed by expert opinion. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random effects model.RESULTS: After incorporating biases, overall effect estimates regressed slightly toward no effect, with the largest relative difference between conventional and bias-adjusted ORs for laboratory-confirmed influenza (OR, 0.18; 95% CI: 0.01, 3.00 vs. OR, 0.23; 95% CI: 0.03, 2.04). In most of the studies, CIs widened reflecting uncertainties about the biases. The between-study heterogeneity reduced considerably with the largest reduction for all-cause mortality (I(2) = 4%, P = 0.39 vs. I(2) = 91%, P < 0.01).CONCLUSION: This case study showed that after addressing potential biases influenza vaccine was still estimated effective in preventing hospitalization from influenza and/or pneumonia and all-cause mortality. Increasing the number of assessors and incorporating empirical evidence might improve the new bias-adjustment method.",
keywords = "Meta-analysis, Bias adjustment, Observational studies, Seasonal influenza, Vaccination, Community-dwelling elderly, CONTROLLED-TRIAL, EFFICACY, HOSPITALIZATIONS, INTERVENTION, PROBABILITY, POPULATION, ADJUSTMENT, REDUCTION, PRECISION, BENEFITS",
author = "Maryam Darvishian and Giedre Gefenaite and Turner, {Rebecca M} and Petros Pechlivanoglou and {Van der Hoek}, Wim and {Van den Heuvel}, {Edwin R} and Eelko Hak",
note = "Copyright {\textcopyright} 2014 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = jul,
doi = "10.1016/j.jclinepi.2014.02.009",
language = "English",
volume = "67",
pages = "734--744",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "ELSEVIER SCIENCE INC",
number = "7",

}

RIS

TY - JOUR

T1 - After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly

AU - Darvishian, Maryam

AU - Gefenaite, Giedre

AU - Turner, Rebecca M

AU - Pechlivanoglou, Petros

AU - Van der Hoek, Wim

AU - Van den Heuvel, Edwin R

AU - Hak, Eelko

N1 - Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVE: To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older.STUDY DESIGN AND SETTING: Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hospitalization from influenza and/or pneumonia, and all-cause mortality were study outcomes. Potential biases were identified using bias checklists. The magnitude and uncertainty of biases were assessed by expert opinion. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random effects model.RESULTS: After incorporating biases, overall effect estimates regressed slightly toward no effect, with the largest relative difference between conventional and bias-adjusted ORs for laboratory-confirmed influenza (OR, 0.18; 95% CI: 0.01, 3.00 vs. OR, 0.23; 95% CI: 0.03, 2.04). In most of the studies, CIs widened reflecting uncertainties about the biases. The between-study heterogeneity reduced considerably with the largest reduction for all-cause mortality (I(2) = 4%, P = 0.39 vs. I(2) = 91%, P < 0.01).CONCLUSION: This case study showed that after addressing potential biases influenza vaccine was still estimated effective in preventing hospitalization from influenza and/or pneumonia and all-cause mortality. Increasing the number of assessors and incorporating empirical evidence might improve the new bias-adjustment method.

AB - OBJECTIVE: To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older.STUDY DESIGN AND SETTING: Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hospitalization from influenza and/or pneumonia, and all-cause mortality were study outcomes. Potential biases were identified using bias checklists. The magnitude and uncertainty of biases were assessed by expert opinion. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random effects model.RESULTS: After incorporating biases, overall effect estimates regressed slightly toward no effect, with the largest relative difference between conventional and bias-adjusted ORs for laboratory-confirmed influenza (OR, 0.18; 95% CI: 0.01, 3.00 vs. OR, 0.23; 95% CI: 0.03, 2.04). In most of the studies, CIs widened reflecting uncertainties about the biases. The between-study heterogeneity reduced considerably with the largest reduction for all-cause mortality (I(2) = 4%, P = 0.39 vs. I(2) = 91%, P < 0.01).CONCLUSION: This case study showed that after addressing potential biases influenza vaccine was still estimated effective in preventing hospitalization from influenza and/or pneumonia and all-cause mortality. Increasing the number of assessors and incorporating empirical evidence might improve the new bias-adjustment method.

KW - Meta-analysis

KW - Bias adjustment

KW - Observational studies

KW - Seasonal influenza

KW - Vaccination

KW - Community-dwelling elderly

KW - CONTROLLED-TRIAL

KW - EFFICACY

KW - HOSPITALIZATIONS

KW - INTERVENTION

KW - PROBABILITY

KW - POPULATION

KW - ADJUSTMENT

KW - REDUCTION

KW - PRECISION

KW - BENEFITS

U2 - 10.1016/j.jclinepi.2014.02.009

DO - 10.1016/j.jclinepi.2014.02.009

M3 - Review article

C2 - 24768004

VL - 67

SP - 734

EP - 744

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

IS - 7

ER -

ID: 13521830