Adversity-driven changes in hypothalamic-pituitary-adrenal axis functioning during adolescence. The trails studyLaceulle, O. M., Nederhof, E., van Aken, M. A. G. & Ormel, J., Nov-2017, In : Psychoneuroendocrinology. 85, p. 49-55 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
The hypothalamic-pituitary-adrenal (HPA) axis has been proposed to be a key mechanism underlying the link between adversity and mental health, but longitudinal studies on adversity and HPA-axis functioning are scarce. Here, we studied adversity-driven changes in HPA-axis functioning during adolescence (N = 141). HPA-axis functioning (basal cortisol, cortisol awakening response, anticipation of, reaction to and recovery after a stress task) was measured twice, at age 16 and 19. Adversity (i.e., social defeat and loss/illness) since age 16 was measured extensively with the Life Stress Interview at age 19. Adolescents who reported being exposed to social defeat showed increases in basal cortisol (eta(2) = 0.029) and decreases in reaction to the stress task (eta(2) = 0.030) from age 16-19, compared to their peers in the loss/illness and no stress group. The current study provides unique longitudinal data on the role of adversity in HPA-axis functioning. Evidence is provided that adversity can affect the body's neuroendocrine response to stress, dependent on the nature of both the HPA-measures and adverse events under study.
|Number of pages||7|
|Publication status||Published - Nov-2017|
- HPA-axis, Social defeat, Longitudinal, Adolescence, Loss, Stressors, CORTISOL RESPONSES, HPA-AXIS, PSYCHOLOGICAL STRESS, CHILDHOOD TRAUMA, SOCIAL STRESS, CHILDREN, ASSOCIATIONS, MALTREATMENT, REACTIVITY, DISORDERS