Publication

Adventitial dissection: a simple and effective way to reduce radial artery spasm in coronary bypass surgery

Sandker, S. C., Mecozzi, G., van Buiten, A., Mariani, M. A., Buikema, H. & Grandjean, J. G., Nov-2013, In : Interactive Cardiovascular and Thoracic Surgery. 17, 5, p. 784-789 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Sandker, S. C., Mecozzi, G., van Buiten, A., Mariani, M. A., Buikema, H., & Grandjean, J. G. (2013). Adventitial dissection: a simple and effective way to reduce radial artery spasm in coronary bypass surgery. Interactive Cardiovascular and Thoracic Surgery, 17(5), 784-789. https://doi.org/10.1093/icvts/ivt312

Author

Sandker, Stefan C. ; Mecozzi, Gianclaudio ; van Buiten, Azuwerus ; Mariani, Massimo A. ; Buikema, Hendrik ; Grandjean, Jan G. / Adventitial dissection : a simple and effective way to reduce radial artery spasm in coronary bypass surgery. In: Interactive Cardiovascular and Thoracic Surgery. 2013 ; Vol. 17, No. 5. pp. 784-789.

Harvard

Sandker, SC, Mecozzi, G, van Buiten, A, Mariani, MA, Buikema, H & Grandjean, JG 2013, 'Adventitial dissection: a simple and effective way to reduce radial artery spasm in coronary bypass surgery', Interactive Cardiovascular and Thoracic Surgery, vol. 17, no. 5, pp. 784-789. https://doi.org/10.1093/icvts/ivt312

Standard

Adventitial dissection : a simple and effective way to reduce radial artery spasm in coronary bypass surgery. / Sandker, Stefan C.; Mecozzi, Gianclaudio; van Buiten, Azuwerus; Mariani, Massimo A.; Buikema, Hendrik; Grandjean, Jan G.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 17, No. 5, 11.2013, p. 784-789.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Sandker SC, Mecozzi G, van Buiten A, Mariani MA, Buikema H, Grandjean JG. Adventitial dissection: a simple and effective way to reduce radial artery spasm in coronary bypass surgery. Interactive Cardiovascular and Thoracic Surgery. 2013 Nov;17(5):784-789. https://doi.org/10.1093/icvts/ivt312


BibTeX

@article{839ea06bf3b742ed955707b554b34ce5,
title = "Adventitial dissection: a simple and effective way to reduce radial artery spasm in coronary bypass surgery",
abstract = "OBJECTIVE: Over the last two decades, the radial artery (RA) has become a routinely used conduit for coronary artery bypass graft surgery. One potential disadvantage of the radial artery is its higher susceptibility to vasospasm compared with other arterial grafts. We investigated whether adventitial dissection of the radial artery can reduce vasoconstriction and increase free blood flow.METHODS: Following harvesting, the adventitia of the radial artery was dissected using coronary scissors. Surplus distal radial artery segments (n = 35) with and without adventitial dissection of patients undergoing coronary artery bypass surgery were collected and pairwise assessment of vasoreactivity to potassium chloride, U46619 and acetylcholine was performed in organ bath experiments. Free blood flow was measured before and after adventitial dissection.RESULTS: Full curve and maximal vasoconstriction of the RA to potassium chloride (P = 0.015 and 0.001) and U46619 (P = 0.048 and 0.001) was significantly reduced after adventitial dissection compared with non-adventitial dissected radial arteries. Endothelium-dependent relaxation to acetylcholine of adventitial dissected radial arteries was significantly increased (P = 0.006) compared with non-adventitial dissected radial arteries. Maximal vasorelaxation to acetylcholine was significantly increased for adventitial dissected radial arteries compared with non-adventitial dissected radial arteries (P = 0.018). Free blood flow was significantly increased after adventitial dissection (P = 0.037).CONCLUSION: The adventitial dissected radial artery is less susceptible to vasoconstriction and more prone to vasorelaxation ex vivo and shows an increased free blood flow. Therefore, we suggest adventitial dissection of the radial artery graft to reduce vasospasm for arterial revascularization in coronary artery bypass surgery.",
keywords = "Coronary artery bypass graft arterial grafts, Vascular tone and reactivity, Coronary artery bypass graft new technology, Off-pump surgery, MAMMARY ARTERY, FREE-FLOW, SKELETONIZATION, GRAFT",
author = "Sandker, {Stefan C.} and Gianclaudio Mecozzi and {van Buiten}, Azuwerus and Mariani, {Massimo A.} and Hendrik Buikema and Grandjean, {Jan G.}",
year = "2013",
month = "11",
doi = "10.1093/icvts/ivt312",
language = "English",
volume = "17",
pages = "784--789",
journal = "Interactive Cardiovascular and Thoracic Surgery",
issn = "1569-9293",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Adventitial dissection

T2 - a simple and effective way to reduce radial artery spasm in coronary bypass surgery

AU - Sandker, Stefan C.

AU - Mecozzi, Gianclaudio

AU - van Buiten, Azuwerus

AU - Mariani, Massimo A.

AU - Buikema, Hendrik

AU - Grandjean, Jan G.

PY - 2013/11

Y1 - 2013/11

N2 - OBJECTIVE: Over the last two decades, the radial artery (RA) has become a routinely used conduit for coronary artery bypass graft surgery. One potential disadvantage of the radial artery is its higher susceptibility to vasospasm compared with other arterial grafts. We investigated whether adventitial dissection of the radial artery can reduce vasoconstriction and increase free blood flow.METHODS: Following harvesting, the adventitia of the radial artery was dissected using coronary scissors. Surplus distal radial artery segments (n = 35) with and without adventitial dissection of patients undergoing coronary artery bypass surgery were collected and pairwise assessment of vasoreactivity to potassium chloride, U46619 and acetylcholine was performed in organ bath experiments. Free blood flow was measured before and after adventitial dissection.RESULTS: Full curve and maximal vasoconstriction of the RA to potassium chloride (P = 0.015 and 0.001) and U46619 (P = 0.048 and 0.001) was significantly reduced after adventitial dissection compared with non-adventitial dissected radial arteries. Endothelium-dependent relaxation to acetylcholine of adventitial dissected radial arteries was significantly increased (P = 0.006) compared with non-adventitial dissected radial arteries. Maximal vasorelaxation to acetylcholine was significantly increased for adventitial dissected radial arteries compared with non-adventitial dissected radial arteries (P = 0.018). Free blood flow was significantly increased after adventitial dissection (P = 0.037).CONCLUSION: The adventitial dissected radial artery is less susceptible to vasoconstriction and more prone to vasorelaxation ex vivo and shows an increased free blood flow. Therefore, we suggest adventitial dissection of the radial artery graft to reduce vasospasm for arterial revascularization in coronary artery bypass surgery.

AB - OBJECTIVE: Over the last two decades, the radial artery (RA) has become a routinely used conduit for coronary artery bypass graft surgery. One potential disadvantage of the radial artery is its higher susceptibility to vasospasm compared with other arterial grafts. We investigated whether adventitial dissection of the radial artery can reduce vasoconstriction and increase free blood flow.METHODS: Following harvesting, the adventitia of the radial artery was dissected using coronary scissors. Surplus distal radial artery segments (n = 35) with and without adventitial dissection of patients undergoing coronary artery bypass surgery were collected and pairwise assessment of vasoreactivity to potassium chloride, U46619 and acetylcholine was performed in organ bath experiments. Free blood flow was measured before and after adventitial dissection.RESULTS: Full curve and maximal vasoconstriction of the RA to potassium chloride (P = 0.015 and 0.001) and U46619 (P = 0.048 and 0.001) was significantly reduced after adventitial dissection compared with non-adventitial dissected radial arteries. Endothelium-dependent relaxation to acetylcholine of adventitial dissected radial arteries was significantly increased (P = 0.006) compared with non-adventitial dissected radial arteries. Maximal vasorelaxation to acetylcholine was significantly increased for adventitial dissected radial arteries compared with non-adventitial dissected radial arteries (P = 0.018). Free blood flow was significantly increased after adventitial dissection (P = 0.037).CONCLUSION: The adventitial dissected radial artery is less susceptible to vasoconstriction and more prone to vasorelaxation ex vivo and shows an increased free blood flow. Therefore, we suggest adventitial dissection of the radial artery graft to reduce vasospasm for arterial revascularization in coronary artery bypass surgery.

KW - Coronary artery bypass graft arterial grafts

KW - Vascular tone and reactivity

KW - Coronary artery bypass graft new technology

KW - Off-pump surgery

KW - MAMMARY ARTERY

KW - FREE-FLOW

KW - SKELETONIZATION

KW - GRAFT

U2 - 10.1093/icvts/ivt312

DO - 10.1093/icvts/ivt312

M3 - Article

VL - 17

SP - 784

EP - 789

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

SN - 1569-9293

IS - 5

ER -

ID: 5988511