Advances of epigenetic editingGjaltema, R. A. F. & Rots, M. G., Aug-2020, In : Current Opinion in Chemical Biology. 57, p. 75-81 7 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.
|Number of pages||7|
|Journal||Current Opinion in Chemical Biology|
|Early online date||29-Jun-2020|
|Publication status||Published - Aug-2020|