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β-Adrenoceptor blocking properties of dl-nebivolol and its enantiomers in the pithed normotensive rat

Schneider, J., Fruh, C., Wilffert, B. & Peters, T., 22-Oct-1991, In : Drug investigation. 3, SUPPL. 1, p. 123-128 6 p.

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In the pithed normotensive rat, the effects of dl-nebivolol and its enantiomers on the (-)-adrenaline (epinephrine)- and electrical stimulation-induced increases in heart rate (HR) and diastolic blood pressure (DBP) were investigated. dl-Nebivolol dose-dependently (10-7to 10-5mol/kg intravenously) antagonised the (-)-adrenaline-induced as well as the electrical stimulation-induced increases in HR, whereas the accompanying increases in DBP were not affected by dl-nebivolol in doses up to 10-5mol/kg. d-Nebivolol dose-dependently (10-8to 10-5mol/kg intravenously) attenuated the (-)-adrenaline-mediated increase in HR. The increase in DBP in the lower dose range of (-)-adrenaline was slightly but significantly (p <0.05) enhanced by d-nebivolol 10-6and 10-5mol/kg. This effect was not dose-dependent and was much smaller than expected for a β2-adrenoceptor blocking drug. The increase in HR elicited by electrical stimulation of the spinal cord was completely blocked by d-nebivolol 10-6mol/kg, whereas the accompanying increase in DBP was not influenced. l-Nebivolol in doses
Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalDrug investigation
Volume3
Issue numberSUPPL. 1
Publication statusPublished - 22-Oct-1991

    Keywords

  • adrenalin, beta adrenergic receptor, beta adrenergic receptor blocking agent, dextro nebivolol, nebivolol, unclassified drug, animal experiment, blood pressure, conference paper, drug effect, drug mixture, enantiomer, heart rate, intravenous drug administration, male, nonhuman, rat, stereoisomerism

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