Publication

ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

Brinksma, D. M., Hoekstra, P. J., de Bildt, A., Buitelaar, J. K., van den Hoofdakker, B. J., Hartman, C. A. & Dietrich, A., Oct-2018, In : Journal of Abnormal Child Psychology. 46, 7, p. 1427-1437 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Brinksma, D. M., Hoekstra, P. J., de Bildt, A., Buitelaar, J. K., van den Hoofdakker, B. J., Hartman, C. A., & Dietrich, A. (2018). ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes. Journal of Abnormal Child Psychology, 46(7), 1427-1437. https://doi.org/10.1007/s10802-017-0377-3

Author

Brinksma, Djuke M. ; Hoekstra, Pieter J. ; de Bildt, Annelies ; Buitelaar, Jan K. ; van den Hoofdakker, Barbara J. ; Hartman, Catharina A. ; Dietrich, Andrea. / ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes. In: Journal of Abnormal Child Psychology. 2018 ; Vol. 46, No. 7. pp. 1427-1437.

Harvard

Brinksma, DM, Hoekstra, PJ, de Bildt, A, Buitelaar, JK, van den Hoofdakker, BJ, Hartman, CA & Dietrich, A 2018, 'ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes' Journal of Abnormal Child Psychology, vol. 46, no. 7, pp. 1427-1437. https://doi.org/10.1007/s10802-017-0377-3

Standard

ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes. / Brinksma, Djuke M.; Hoekstra, Pieter J.; de Bildt, Annelies; Buitelaar, Jan K.; van den Hoofdakker, Barbara J.; Hartman, Catharina A.; Dietrich, Andrea.

In: Journal of Abnormal Child Psychology, Vol. 46, No. 7, 10.2018, p. 1427-1437.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Brinksma DM, Hoekstra PJ, de Bildt A, Buitelaar JK, van den Hoofdakker BJ, Hartman CA et al. ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes. Journal of Abnormal Child Psychology. 2018 Oct;46(7):1427-1437. https://doi.org/10.1007/s10802-017-0377-3


BibTeX

@article{77fc8e1a6f96463093d5362513888bf0,
title = "ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes",
abstract = "Literature suggests that life stressors predict attention-deficit/hyperactivity disorder (ADHD) symptoms and that this relationship is moderated by the serotonin transporter polymorphism (5-HTTLPR). It is less clear whether, on reverse, ADHD symptoms may influence the risk of exposure to life stressors. Furthermore, the role of life stressors may vary across development depending on the type of life stressor. We used threewave longitudinal data of 1,306 adolescents from the general population and clinicreferred cohort of the TRacking Adolescents' Individual Lives Survey. The 5-HTTLPR genotype (SS, LS, LL), parent-reported ADHD symptoms at three time points (T1: Mage=11.2; T2: Mage=13.5; T3: Mage=16.2years), and the number of personrelated (dependent') and environment-related (independent') life stressors occurring between measurements (T1-T2, T2-T3) were assessed. Using path analyses, we examined bidirectional relations between exposure to these life stressors and ADHD symptoms between the separate waves moderated by 5-HTTLPR status. Exposure to life stressors did not predict ADHD symptoms. Rather, we found that in 5-HTTLPR Sallele homozygotes, ADHD symptoms in middle adolescence (T2) predicted exposure to the number of person-related life stressors later in adolescence (T2-T3, p=0.001). There was no relation with environment-related life stressors. Our study suggests that S-allele homozygotes with higher levels of ADHD symptoms in middle adolescence are more vulnerable to becoming exposed to person-related (dependent') life stressors in late adolescence. Findings emphasize the need to be aware of social-emotional adversities that may occur in genetically vulnerable adolescents with ADHD symptoms in the transition into adulthood.",
keywords = "ADHD, Adolescence, Gene-environment interaction, Life stressors, 5-HTTLPR, Development, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DEFICIT HYPERACTIVITY DISORDER, SEROTONIN TRANSPORTER GENE, ENVIRONMENTAL-INFLUENCES, MENTAL-HEALTH, LATE CHILDHOOD, DEPRESSION, EVENTS, TRAILS, PSYCHOPATHOLOGY",
author = "Brinksma, {Djuke M.} and Hoekstra, {Pieter J.} and {de Bildt}, Annelies and Buitelaar, {Jan K.} and {van den Hoofdakker}, {Barbara J.} and Hartman, {Catharina A.} and Andrea Dietrich",
year = "2018",
month = "10",
doi = "10.1007/s10802-017-0377-3",
language = "English",
volume = "46",
pages = "1427--1437",
journal = "J Abnorm Child Psychol",
issn = "0091-0627",
publisher = "SPRINGER/PLENUM PUBLISHERS",
number = "7",

}

RIS

TY - JOUR

T1 - ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

AU - Brinksma, Djuke M.

AU - Hoekstra, Pieter J.

AU - de Bildt, Annelies

AU - Buitelaar, Jan K.

AU - van den Hoofdakker, Barbara J.

AU - Hartman, Catharina A.

AU - Dietrich, Andrea

PY - 2018/10

Y1 - 2018/10

N2 - Literature suggests that life stressors predict attention-deficit/hyperactivity disorder (ADHD) symptoms and that this relationship is moderated by the serotonin transporter polymorphism (5-HTTLPR). It is less clear whether, on reverse, ADHD symptoms may influence the risk of exposure to life stressors. Furthermore, the role of life stressors may vary across development depending on the type of life stressor. We used threewave longitudinal data of 1,306 adolescents from the general population and clinicreferred cohort of the TRacking Adolescents' Individual Lives Survey. The 5-HTTLPR genotype (SS, LS, LL), parent-reported ADHD symptoms at three time points (T1: Mage=11.2; T2: Mage=13.5; T3: Mage=16.2years), and the number of personrelated (dependent') and environment-related (independent') life stressors occurring between measurements (T1-T2, T2-T3) were assessed. Using path analyses, we examined bidirectional relations between exposure to these life stressors and ADHD symptoms between the separate waves moderated by 5-HTTLPR status. Exposure to life stressors did not predict ADHD symptoms. Rather, we found that in 5-HTTLPR Sallele homozygotes, ADHD symptoms in middle adolescence (T2) predicted exposure to the number of person-related life stressors later in adolescence (T2-T3, p=0.001). There was no relation with environment-related life stressors. Our study suggests that S-allele homozygotes with higher levels of ADHD symptoms in middle adolescence are more vulnerable to becoming exposed to person-related (dependent') life stressors in late adolescence. Findings emphasize the need to be aware of social-emotional adversities that may occur in genetically vulnerable adolescents with ADHD symptoms in the transition into adulthood.

AB - Literature suggests that life stressors predict attention-deficit/hyperactivity disorder (ADHD) symptoms and that this relationship is moderated by the serotonin transporter polymorphism (5-HTTLPR). It is less clear whether, on reverse, ADHD symptoms may influence the risk of exposure to life stressors. Furthermore, the role of life stressors may vary across development depending on the type of life stressor. We used threewave longitudinal data of 1,306 adolescents from the general population and clinicreferred cohort of the TRacking Adolescents' Individual Lives Survey. The 5-HTTLPR genotype (SS, LS, LL), parent-reported ADHD symptoms at three time points (T1: Mage=11.2; T2: Mage=13.5; T3: Mage=16.2years), and the number of personrelated (dependent') and environment-related (independent') life stressors occurring between measurements (T1-T2, T2-T3) were assessed. Using path analyses, we examined bidirectional relations between exposure to these life stressors and ADHD symptoms between the separate waves moderated by 5-HTTLPR status. Exposure to life stressors did not predict ADHD symptoms. Rather, we found that in 5-HTTLPR Sallele homozygotes, ADHD symptoms in middle adolescence (T2) predicted exposure to the number of person-related life stressors later in adolescence (T2-T3, p=0.001). There was no relation with environment-related life stressors. Our study suggests that S-allele homozygotes with higher levels of ADHD symptoms in middle adolescence are more vulnerable to becoming exposed to person-related (dependent') life stressors in late adolescence. Findings emphasize the need to be aware of social-emotional adversities that may occur in genetically vulnerable adolescents with ADHD symptoms in the transition into adulthood.

KW - ADHD

KW - Adolescence

KW - Gene-environment interaction

KW - Life stressors

KW - 5-HTTLPR

KW - Development

KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

KW - DEFICIT HYPERACTIVITY DISORDER

KW - SEROTONIN TRANSPORTER GENE

KW - ENVIRONMENTAL-INFLUENCES

KW - MENTAL-HEALTH

KW - LATE CHILDHOOD

KW - DEPRESSION

KW - EVENTS

KW - TRAILS

KW - PSYCHOPATHOLOGY

U2 - 10.1007/s10802-017-0377-3

DO - 10.1007/s10802-017-0377-3

M3 - Article

VL - 46

SP - 1427

EP - 1437

JO - J Abnorm Child Psychol

JF - J Abnorm Child Psychol

SN - 0091-0627

IS - 7

ER -

ID: 65010848