Publication

Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer: A retrospective cohort study

Leimkühler, M., de Haas, R. J., Pol, V. E. H., Hemmer, P. H. J., Been, L. B., van Ginkel, R. J., Kruijff, S., de Bock, G. H. & van Leeuwen, B. L., Jun-2020, In : Surgical oncology-Oxford. 33, p. 135-140 6 p.

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APA

Leimkühler, M., de Haas, R. J., Pol, V. E. H., Hemmer, P. H. J., Been, L. B., van Ginkel, R. J., ... van Leeuwen, B. L. (2020). Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer: A retrospective cohort study. Surgical oncology-Oxford, 33, 135-140. https://doi.org/10.1016/j.suronc.2020.02.010

Author

Leimkühler, Maleen ; de Haas, Robbert J ; Pol, Vincent E H ; Hemmer, Patrick H J ; Been, Lukas B ; van Ginkel, Robert J ; Kruijff, Schelto ; de Bock, Geertruida H ; van Leeuwen, Barbara L. / Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer : A retrospective cohort study. In: Surgical oncology-Oxford. 2020 ; Vol. 33. pp. 135-140.

Harvard

Leimkühler, M, de Haas, RJ, Pol, VEH, Hemmer, PHJ, Been, LB, van Ginkel, RJ, Kruijff, S, de Bock, GH & van Leeuwen, BL 2020, 'Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer: A retrospective cohort study', Surgical oncology-Oxford, vol. 33, pp. 135-140. https://doi.org/10.1016/j.suronc.2020.02.010

Standard

Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer : A retrospective cohort study. / Leimkühler, Maleen; de Haas, Robbert J; Pol, Vincent E H; Hemmer, Patrick H J; Been, Lukas B; van Ginkel, Robert J; Kruijff, Schelto; de Bock, Geertruida H; van Leeuwen, Barbara L.

In: Surgical oncology-Oxford, Vol. 33, 06.2020, p. 135-140.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Leimkühler M, de Haas RJ, Pol VEH, Hemmer PHJ, Been LB, van Ginkel RJ et al. Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer: A retrospective cohort study. Surgical oncology-Oxford. 2020 Jun;33:135-140. https://doi.org/10.1016/j.suronc.2020.02.010


BibTeX

@article{1460087e30ea4283a71bee804af7fbd4,
title = "Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer: A retrospective cohort study",
abstract = "BACKGROUND: Despite its widespread use, computed tomography (CT) is not perfect for evaluating peritoneal metastases of colorectal origin before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). We therefore evaluated the value of adding diagnostic laparoscopy to CT when assessing patient eligibility for CRS + HIPEC.METHODS: This was a retrospective study of a consecutive series of 112 patients evaluated systematically by diagnostic laparoscopy and CT between January 2012 and January 2018. Patient eligibility for CRS + HIPEC was assessed by the peritoneal cancer index (PCI) both at the time of initial diagnostic laparoscopy and during the retrospective review of CT images. Two experienced radiologists who were blinded to the PCI result at laparoscopy then independently estimated the PCI based on CT imaging. The primary outcome was the number of patients eligible for CRS + HIPEC by each method.RESULTS: We identified 112 patients, of whom 95 (85{\%}) were eligible for CRS + HIPEC based on diagnostic laparoscopy and 84 underwent CRS + HIPEC. Overall, 14 patients (17{\%}) experienced an {"}open-and-close{"} procedure. In contrast to diagnostic laparoscopy, 100 patients (89{\%}) were identified as being eligible for CRS + HIPEC by CT (p = 0.13), which would have resulted in an additional five open-and-close procedures.CONCLUSIONS: Adding diagnostic laparoscopy to CT produced a clinically relevant, but statistically non-significant, reduction in the number of patients eligible for CRS + HIPEC. We conclude that diagnostic laparoscopy may be of use in preoperative assessments when systematic analysis by CT scores the PCI as greater than ten. Future research should focus on the cost-effectiveness of this approach.",
author = "Maleen Leimk{\"u}hler and {de Haas}, {Robbert J} and Pol, {Vincent E H} and Hemmer, {Patrick H J} and Been, {Lukas B} and {van Ginkel}, {Robert J} and Schelto Kruijff and {de Bock}, {Geertruida H} and {van Leeuwen}, {Barbara L}",
note = "Copyright {\circledC} 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2020",
month = "6",
doi = "10.1016/j.suronc.2020.02.010",
language = "English",
volume = "33",
pages = "135--140",
journal = "Surgical oncology-Oxford",
issn = "0960-7404",
publisher = "ELSEVIER SCI LTD",

}

RIS

TY - JOUR

T1 - Adding diagnostic laparoscopy to computed tomography for the evaluation of peritoneal metastases in patients with colorectal cancer

T2 - A retrospective cohort study

AU - Leimkühler, Maleen

AU - de Haas, Robbert J

AU - Pol, Vincent E H

AU - Hemmer, Patrick H J

AU - Been, Lukas B

AU - van Ginkel, Robert J

AU - Kruijff, Schelto

AU - de Bock, Geertruida H

AU - van Leeuwen, Barbara L

N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: Despite its widespread use, computed tomography (CT) is not perfect for evaluating peritoneal metastases of colorectal origin before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). We therefore evaluated the value of adding diagnostic laparoscopy to CT when assessing patient eligibility for CRS + HIPEC.METHODS: This was a retrospective study of a consecutive series of 112 patients evaluated systematically by diagnostic laparoscopy and CT between January 2012 and January 2018. Patient eligibility for CRS + HIPEC was assessed by the peritoneal cancer index (PCI) both at the time of initial diagnostic laparoscopy and during the retrospective review of CT images. Two experienced radiologists who were blinded to the PCI result at laparoscopy then independently estimated the PCI based on CT imaging. The primary outcome was the number of patients eligible for CRS + HIPEC by each method.RESULTS: We identified 112 patients, of whom 95 (85%) were eligible for CRS + HIPEC based on diagnostic laparoscopy and 84 underwent CRS + HIPEC. Overall, 14 patients (17%) experienced an "open-and-close" procedure. In contrast to diagnostic laparoscopy, 100 patients (89%) were identified as being eligible for CRS + HIPEC by CT (p = 0.13), which would have resulted in an additional five open-and-close procedures.CONCLUSIONS: Adding diagnostic laparoscopy to CT produced a clinically relevant, but statistically non-significant, reduction in the number of patients eligible for CRS + HIPEC. We conclude that diagnostic laparoscopy may be of use in preoperative assessments when systematic analysis by CT scores the PCI as greater than ten. Future research should focus on the cost-effectiveness of this approach.

AB - BACKGROUND: Despite its widespread use, computed tomography (CT) is not perfect for evaluating peritoneal metastases of colorectal origin before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). We therefore evaluated the value of adding diagnostic laparoscopy to CT when assessing patient eligibility for CRS + HIPEC.METHODS: This was a retrospective study of a consecutive series of 112 patients evaluated systematically by diagnostic laparoscopy and CT between January 2012 and January 2018. Patient eligibility for CRS + HIPEC was assessed by the peritoneal cancer index (PCI) both at the time of initial diagnostic laparoscopy and during the retrospective review of CT images. Two experienced radiologists who were blinded to the PCI result at laparoscopy then independently estimated the PCI based on CT imaging. The primary outcome was the number of patients eligible for CRS + HIPEC by each method.RESULTS: We identified 112 patients, of whom 95 (85%) were eligible for CRS + HIPEC based on diagnostic laparoscopy and 84 underwent CRS + HIPEC. Overall, 14 patients (17%) experienced an "open-and-close" procedure. In contrast to diagnostic laparoscopy, 100 patients (89%) were identified as being eligible for CRS + HIPEC by CT (p = 0.13), which would have resulted in an additional five open-and-close procedures.CONCLUSIONS: Adding diagnostic laparoscopy to CT produced a clinically relevant, but statistically non-significant, reduction in the number of patients eligible for CRS + HIPEC. We conclude that diagnostic laparoscopy may be of use in preoperative assessments when systematic analysis by CT scores the PCI as greater than ten. Future research should focus on the cost-effectiveness of this approach.

U2 - 10.1016/j.suronc.2020.02.010

DO - 10.1016/j.suronc.2020.02.010

M3 - Article

C2 - 32561078

VL - 33

SP - 135

EP - 140

JO - Surgical oncology-Oxford

JF - Surgical oncology-Oxford

SN - 0960-7404

ER -

ID: 128421484