Adaptive radiotherapy for invasive bladder cancer: A feasibility study

Pos, F. J., Hulshof, M. C., Lebesque, J., Lotz, H., Van Tienhoven, G., Moonen, L. & Remeijer, P., 1-Mar-2006, In : International Journal of Radiation Oncology, Biology, Physics. 64, 3, p. 862-868 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Floris J. Pos
  • Maarten C. Hulshof
  • Joos Lebesque
  • Heidi Lotz
  • Geertjan Van Tienhoven
  • Luc Moonen
  • Peter Remeijer
Purpose: To evaluate the feasibility of adaptive radiotherapy (ART) in combination with a partial bladder irradiation. Methods and Materials: Twenty-one patients with solitary T1–T4 N0M0 bladder cancer were treated to the bladder tumor + 2 cm margin planning target volume (PTVCONV). During the first treatment week, five daily computed tomography (CT) scans were made immediately before or after treatment. In the second week, a volume was constructed encompassing the gross tumor volumes (GTVs) on the planning scan and the five CT scans (GTVART). The GTVART was expanded with a 1 cm margin for the construction of a PTVART. Starting in the third week, patients were treated to PTVART. Repeat CT scans were used to evaluate treatment accuracy. Results: On 5 of 91 repeat CT scans (5%), the GTV was not adequately covered by the PTVART. On treatment planning, there was only one scan in which the GTV was not adequately covered by the 95% isodose. On average, the treatment volumes were reduced by 40% when comparing PTVART with PTVCONV (p < 0.0001). Conclusion: The adaptive strategy for bladder cancer is an effective way to deal with treatment errors caused by variations in bladder tumor position and leads to a substantial reduction in treatment volumes.
Original languageEnglish
Pages (from-to)862-868
Number of pages7
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number3
Publication statusPublished - 1-Mar-2006
Externally publishedYes

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