Publication

ACUTE RENAL EFFECTS OF SOMATOSTATIN ANALOG, OCTREOTIDE, IN INSULIN-DEPENDENT DIABETIC-PATIENTS - ANTAGONISM BY LOW-DOSE GLUCAGON

STEGEMAN, CA., DULLAART, RPF., MEIJER, S., MARBACH, P. & SLUITER, WJ., Apr-1993, In : Diabetes nutrition & metabolism. 6, 2, p. 87-95 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Thirty patients affected by insulin-dependent diabetes mellitus, without overt diabetic nephropathy, were randomly allocated to receive either octreotide (20 mug bolus followed by 10 mug.h-1) or vehicle intravenously over 2 hr. A similar infusion of octreotide with concomitant glucagon infusion (2 to 3 ng.kg bodyweight-1.min-1) was administered to 13 of these patients on a separate day. Octreotide decreased glomerular filtration rate by 6.3 ml.min-1.1.73m-2 (median, 95% CI 21.8 to 58.7; p

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalDiabetes nutrition & metabolism
Volume6
Issue number2
Publication statusPublished - Apr-1993

    Keywords

  • FREE WATER CLEARANCE, GLUCAGON, INSULIN-DEPENDENT DIABETES-MELLITUS, OCTREOTIDE, RENAL HEMODYNAMICS, EARLY GLOMERULAR HYPERFILTRATION, KIDNEY-FUNCTION, GROWTH-HORMONE, ANTIHYPERTENSIVE TREATMENT, JUVENILE DIABETICS, LATE NEPHROPATHY, MELLITUS, PLASMA, PROGRESSION, EXTRACTION

ID: 6347832